典型文献
Bacteremia tuberculosis among HIV-negative children in China
文献摘要：
Importance::Bacteremia tuberculosis (TB) is a severe form of extrapulmonary TB. Studies assessing bacteremia TB in children are limited, especially for HIV-negative children.Objective::To explore the detailed clinical features of the bacteremia TB in children under 18 years of age.Methods::We reviewed the clinical records of the patients retrospectively and collected the strains isolated from their blood cultures. We used mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) to characterize the bacterial genotypes and alamarBlue to determine their drug susceptibility profiles. Polymerase chain reactions and DNA sequencing were used to identify drug-resistant mutations.Results::There were 13 pediatric bacteremia TB patients, 10 of whom were diagnosed with Bacillus Calmette–Guérin (BCG) bacteremia TB. Thirteen patients aged from 0.30 to 11.58 years were enrolled, of whom 76.92% were boys. All had fevers before hospitalization, and 76.92% had respiratory symptoms. All had received BCG vaccinations, and 46.15% had adverse post-vaccination reactions. Compared with
Mycobacterium tuberculosis, BCG bacteremia was more likely to appear in younger children. Patients with BCG bacteremia had primary immunodeficiency diseases, and lower CD4, IgA, and IgE levels.
Interpretation::Bacteremia TB was rapidly fatal in a large proportion of the immunodeficient children. Because classic findings may not be diagnostically specific, a high level of clinical suspicion is required, especially for patients with certain types of immunosuppression. Studies are needed to develop rapid diagnostic tests and to determine the value of empirical therapy in childhood bacteremia TB.
文献关键词：
Bacteremia tuberculosis;HIV negative;Children;China
中图分类号：
作者姓名：
Chu Ping;Shi Jin;Dong Fang;Yang Hui;Zhao Shunying;Liu Gang;Zheng Huyong;Liu Jinrong;Li Huimin;Lu Jie
作者机构：
Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University & Capital Medical University, Beijing, China;Department of Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China;Department of Laboratory Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;Department 2 of Respiratory Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;Department of Infectious Disease, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics, Ministry of Education, Key Laboratory of Major Diseases in Children, Ministry of Education, Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
文献出处：
引用格式：
[1]Chu Ping;Shi Jin;Dong Fang;Yang Hui;Zhao Shunying;Liu Gang;Zheng Huyong;Liu Jinrong;Li Huimin;Lu Jie-.Bacteremia tuberculosis among HIV-negative children in China)[J].儿科学研究（英文）,2022(03):197-206
A类：
Bacteremia,bacteremia,alamarBlue,diagnostically
B类：
tuberculosis,among,HIV,negative,children,China,Importance,TB,severe,form,extrapulmonary,Studies,assessing,limited,especially,Objective,To,explore,detailed,clinical,features,under,years,Methods,We,reviewed,records,patients,retrospectively,collected,strains,isolated,from,their,blood,cultures,used,mycobacterial,interspersed,repetitive,unit,variable,number,tandem,repeat,MIRU,VNTR,characterize,genotypes,determine,drug,susceptibility,profiles,Polymerase,chain,reactions,sequencing,were,identify,resistant,mutations,Results,There,pediatric,whom,diagnosed,Bacillus,Calmette,Gu,rin,BCG,Thirteen,aged,enrolled,boys,All,had,fevers,before,hospitalization,respiratory,symptoms,received,vaccinations,adverse,post,Compared,Mycobacterium,was,more,likely,appear,younger,Patients,primary,immunodeficiency,diseases,lower,CD4,IgA,IgE,levels,Interpretation,rapidly,fatal,large,proportion,immunodeficient,Because,classic,findings,may,specific,high,suspicion,required,certain,immunosuppression,needed,develop,tests,value,empirical,therapy,childhood,Children
AB值：
0.564142
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