典型文献
Searching for the emotional roots of breast cancer:A cross-disciplinary analysis integrating psychology,Chinese medicine,and oncology biomarkers
文献摘要：
Objective:We employed a multidisciplinary approach incorporating theoretical ideas,clinical experience,psychology,physiology,traditional Chinese medicine (CM),modern practice of CM,and oncology to explore the effect of patients' repression of negative emotions and traumatic events on breast cancer(BC) pathogenesis.Methods:BC female patients,older than 18 years of age,with available pathology reports who were trea-ted at Rabin Medical Center were recruited.All participants completed questionnaires regarding medical history,behavioral tendencies,negative emotions,trauma,symptoms,and pathology (from a CM per-spective).Data on tumor characteristics were collected from the pathology reports.The associations were examined using hierarchical binary logistic regressions.Results:A total of 155 BC patients were enrolled.The median age was 52 years,with a range of 26-79;95％ were mothers;28％ had estrogen receptor (ER)-negative BC,52％ had progesterone receptor (PR)-negative BC,48％ had human epidermal growth factor receptor 2-negative BC,and antigen Ki-67 ≥ 20％was reported for 52％ of tumors.Statistically significant associations were found between the emotional markers (sense of motherhood failure,and lack of self-fulfillment),avoidance behavior,and physical symptoms that are related to emotional repression based on CM.Significant associations were also found between variables associated with physical symptoms of emotional repression,which involves the pro-duction and accumulation of non-substantial phlegm (i.e.,"high-lipid Qi-like microscopic phlegm"),avoidance behavior which unconsciously uses "high-lipid Qi-like microscopic phlegm" in order to achieve emotional repression,and tumor parameters including tumor grade,PR status,and Ki-67.Patients with higher levels of "high-lipid Qi-like microscopic phlegm" were more likely to have tumors with worse prognosis (PR-negative,higher grade,and higher Ki-67).Conclusion:We demonstrated a relationship between emotional parameters,behavioral tendencies,CM parameters,and oncologic parameters in BC.Additional research is warranted to explore these associa-tions and their relevance to clinical practice.
文献关键词：
中图分类号：
作者姓名：
Ofer Baranovitch;Meirav Wolff-Bar;Meora Feinmesser;Chen Sade-Zaltz;Ilan Tsarfaty;Victoria Neiman
作者机构：
Integrative Unit,Davidoff Cancer Center,Rabin Medical Center,Petach Tikva 4941492,Israel;Maccabi Tivi (Maccabi Health Organization),Tel Aviv 6801294,Israel;Department of Pathology,Rabin Medical Center,Petach Tikva 4941492,Israel;Sackler Faculty of Medicine,Tel Aviv University,Tel Aviv 6997801,Israel;Department of Clinical Microbiology and Immunology,Sackler School of Medicine,Tel Aviv University,Tel Aviv 6997801,Israel;Institute of Oncology,Davidoff Cancer Center,Rabin Medical Center,Petach Tikva 4941492,Israel
文献出处：
引用格式：
[1]Ofer Baranovitch;Meirav Wolff-Bar;Meora Feinmesser;Chen Sade-Zaltz;Ilan Tsarfaty;Victoria Neiman-.Searching for the emotional roots of breast cancer:A cross-disciplinary analysis integrating psychology,Chinese medicine,and oncology biomarkers)[J].结合医学学报（英文版）,2022(01):57-64
A类：
motherhood
B类：
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AB值：
0.540313
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