典型文献
Cytogenetic Characteristics of Childhood Acute Lymphoblastic Leukemia:A Study of 1541 Chinese Patients Newly Diagnosed between 2001 and 2014
文献摘要：
Objective:Cytogenetic abnormalities have been proven to be the most valuable parameter for risk stratification of childhood acute lymphoblastic leukemia(ALL).However,studies on the prevalence of cytogenetic abnormalities and their correlation to clinical features in Chinese pediatric patients are limited,especially large-scale studies.Methods:We collected the cytogenetics and clinical data of 1541 children newly diagnosed with ALL between 2001 and 2014 in four Chinese hospitals,and retrospectively analyzed their clinical features,prognosis and risk factors associated with pediatric ALL.Results:All of these patients had karyotyping results,and some of them were tested for fusion genes by fluorescence in situ hybridization or reverse-transcription polymerase chain reaction.Overall,930 cases(60.4％)had abnormal cytogenetics in this study,mainly including high hyperdiploidy(HHD,n=276,17.9％),hypodiploidy(n=74,4.8％),t(12;21)/TEL-AML 1(n=260,16.9％),t(1;19)/E2A-PBX1(n=72,4.7％),t(9;22)/BCR-ABL(n=64,4.2％),and t(v;11q23)/MLL rearrangements(n=40,2.6％).The distribution of each cytogenetic abnormality was correlated with gender,age,white blood cell count at diagnosis,and immunophenotype.In addition,multivariate analysis suggested that t(v;11q23)/MLL rearrangements(OR:2.317,95％CI:1.219-3.748,P=0.008)and t(9;22)/BCR-ABL(OR:2.519,95％CI:1.59-3.992,P＜0.001)were independent risk factors for a lower event-free survival(EFS)rate in children with ALL,while HHD(OR:0.638,95％CI:0.455-0.894,P=0.009)and t(12;21)/TEL-AML1(OR:0.486,95％CI:0.333-0.707,P＜0.001)were independent factors of a favorable EFS.Conclusion:The cytogenetic characteristics presented in our study resembled other research groups,emphasizing the important role of cytogenetic and molecular genetic classification in ALL,especially in B-ALL.
文献关键词：
中图分类号：
作者姓名：
Meng-meng YIN;Rui-chi WU;Jing GAO;Shao-yan HU;Xiao-ming LIU;Xiao-fan ZHU;Shu-hong SHEN;Jing-yan TANG;Jing CHEN;Qun HU
作者机构：
Department of Pediatric Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Hematology/Oncology,Shanghai Children's Medical Center,Shanghai Jiaotong University School of Medicine,Shanghai 200000,China;Children's Hospital of Soochow University,Suzhou 215000,China;State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300000,China
文献出处：
引用格式：
[1]Meng-meng YIN;Rui-chi WU;Jing GAO;Shao-yan HU;Xiao-ming LIU;Xiao-fan ZHU;Shu-hong SHEN;Jing-yan TANG;Jing CHEN;Qun HU-.Cytogenetic Characteristics of Childhood Acute Lymphoblastic Leukemia:A Study of 1541 Chinese Patients Newly Diagnosed between 2001 and 2014)[J].当代医学科学(英文),2022(01):201-209
A类：
Cytogenetic,Lymphoblastic,Diagnosed,hyperdiploidy,hypodiploidy,immunophenotype
B类：
Characteristics,Childhood,Acute,Leukemia,Study,Chinese,Patients,Newly,between,Objective,abnormalities,have,been,proven,most,valuable,parameter,risk,stratification,childhood,acute,lymphoblastic,leukemia,ALL,However,studies,prevalence,their,correlation,clinical,features,pediatric,patients,are,limited,especially,large,scale,Methods,We,collected,cytogenetics,data,children,newly,diagnosed,four,hospitals,retrospectively,analyzed,prognosis,factors,associated,Results,All,these,had,karyotyping,results,some,them,were,tested,fusion,genes,by,fluorescence,situ,hybridization,reverse,transcription,polymerase,chain,reaction,Overall,cases,this,study,mainly,including,high,HHD,TEL,E2A,PBX1,BCR,ABL,11q23,MLL,rearrangements,distribution,each,abnormality,was,correlated,gender,age,white,blood,cell,count,diagnosis,In,addition,multivariate,analysis,suggested,that,independent,lower,event,free,survival,EFS,rate,while,AML1,favorable,Conclusion,characteristics,presented,resembled,other,research,groups,emphasizing,important,role,molecular,classification
AB值：
0.593655
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