典型文献
Antimicrobial susceptibility and serotypes of Neisseria meningitidis and Streptococcus pneumoniae in Sri Lanka: Experience from the National Reference Laboratory
文献摘要：
Objective: To determine the antimicrobial susceptibility and serotypes of Neisseria (N.) meningitidis and Streptococcus (S.) pneumoniae in Sri Lankan patients. Methods: We retrospectively analyzed 11 blood culture specimens from suspected patients with invasive meningococcal disease and 26 S. pneumoniae clinical isolates. We tested 6 antimicrobials against N. meningitidis and 12 antimicrobials against S. pneumoniae. Meningococcal serogroup was determined by realtime PCR and Quellung serotyping was used for pneumococcal analysis. Results: N. meningitidis serogroup B was the most common in this study. Intermediate-susceptibility to penicillin was seen in 75.0％ (6/8) of strains. Susceptibility to ciprofloxacin, levofloxacin and cotrimoxazole was 62.5％ (5/8), 62.5％ (5/8) and 87.5％ (7/8), respectively. Excellent susceptibility was seen in cefotaxime and meropenem. In S. pneumoniae, the most common serotype was 19F in both invasive and non-invasive pneumococcal diseases. The majority of strains showed multidrug resistance. Penicillin non-susceptibility in non-meningeal strains were 13.6％ and all meningeal strains were penicillin resistant. Erythromycin was highly resistant in both groups. Amoxicillin showed excellent susceptibility in non-invasive pneumococcal diseases strains. Linezolid, levofloxacin and vancomycin showed 100.0％ susceptibility in all pneumococcal isolates. Conclusions: Implementation of vaccines should be considered, especially for children and high-risk populations. This may contribute to reducing pneumococcal and meningococcal invasive disease burden and help prevent emergence of antimicrobial resistant strains.
文献关键词：
中图分类号：
作者姓名：
Lilani Karunanayake;Veeraraghavan Balaji;K.D.N.Gunawardana;Rosemol Varghese;Vayishnavi Ariram;Malka Dassanayake;Vaithehi Rajeevan Francis;Lakmini Yapa;Chamika Herath;Nambage Shirani Chandrasiri;Priyanka Wimalagunawardhana;K.Dhananja Namalie;C.T.Hapuarachchi
作者机构：
Department of Bacteriology,Medical Research Institute,Colombo,Sri Lanka;Department of Microbiology,Christian Medical College,Vellore,India;Lady Ridgeway Children's Hospital,Colombo,Sri Lanka;Department of Pathophysiology,Faculty of Healthcare Sciences,Eastern University,Sri Lanka;Teaching Hospital,Anuradhapura,Sri Lanka;District General Hospital,Moneragala,Sri Lanka;Colombo South Teaching Hospital,Kalubowila,Sri Lanka;District General Hospital,Polonnaruwa,Sri Lanka;North Colombo Teaching Hospital,Ragama,Sri Lanka;District General Hospital,Mannar,Sri Lanka
文献出处：
引用格式：
[1]Lilani Karunanayake;Veeraraghavan Balaji;K.D.N.Gunawardana;Rosemol Varghese;Vayishnavi Ariram;Malka Dassanayake;Vaithehi Rajeevan Francis;Lakmini Yapa;Chamika Herath;Nambage Shirani Chandrasiri;Priyanka Wimalagunawardhana;K.Dhananja Namalie;C.T.Hapuarachchi-.Antimicrobial susceptibility and serotypes of Neisseria meningitidis and Streptococcus pneumoniae in Sri Lanka: Experience from the National Reference Laboratory)[J].亚太热带医药杂志（英文版）,2022(03):114-120
A类：
Lankan,Meningococcal,serogroup,Quellung,serotyping,cotrimoxazole,Penicillin,Amoxicillin,Linezolid
B类：
Antimicrobial,susceptibility,serotypes,Neisseria,meningitidis,Streptococcus,pneumoniae,Sri,Experience,from,National,Reference,Laboratory,Objective,To,patients,Methods,We,retrospectively,analyzed,blood,culture,specimens,suspected,invasive,meningococcal,clinical,isolates,tested,antimicrobials,against,was,determined,by,realtime,used,pneumococcal,analysis,Results,most,common,this,study,Intermediate,penicillin,seen,strains,Susceptibility,ciprofloxacin,levofloxacin,respectively,Excellent,cefotaxime,meropenem,19F,both,diseases,majority,showed,multidrug,resistance,meningeal,were,resistant,Erythromycin,highly,groups,excellent,vancomycin,Conclusions,Implementation,vaccines,should,be,considered,especially,children,risk,populations,This,may,contribute,reducing,burden,help,prevent,emergence
AB值：
0.454616
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