典型文献
The development from hyperuricemia to gout:key mechanisms and natural products for treatment
文献摘要：
Gout is a common of infiammatory arthritis and is caused by the deposition of monosodium urate (MSU) crystals as a result of hyperuricemia (HUA). Although HUA is considered to be the main risk factor for gout, only approximately 10％of the individuals with HUA will eventually experience a gout attack. In this review, we first briefiy introduce the development of gout and then summarize several possible reasons for its development. Genetic factors play a more prominent role in gout than in other diseases;functional mutations related to urate control and innate immunity components have been found to be associated with gout. Here, we list some of the most prominent genes involved in the pathogenesis of gout. In joints with MSU deposition, mature macrophages may uptake MSU crystals without causing infiammation, and this helps to maintain joints in an asymptomatic state. As an auxiliary infiammation pathway, the ATP-P2X7R-NLRP3 axis may contribute to the amplification of MSU-induced infiammation to affect the development of gout. Finally, this review summarizes the research progress on natural products that can be used in the treatment of HUA and gout.
文献关键词：
中图分类号：
作者姓名：
Lin Liu;Dan Wang;Mengyang Liu;Haiyang Yu;Qian Chen;Yuzheng Wu;Ruixia Bao;Yi Zhang;Tao Wang
作者机构：
Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,China;Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae,Ministry of Education,Tianjin University of Traditional Chinese Medicine,Tianjin,China;State Key Laboratory of Component-based Chinese Medicine,Tianjin,China
文献出处：
引用格式：
[1]Lin Liu;Dan Wang;Mengyang Liu;Haiyang Yu;Qian Chen;Yuzheng Wu;Ruixia Bao;Yi Zhang;Tao Wang-.The development from hyperuricemia to gout:key mechanisms and natural products for treatment)[J].针灸和草药（英文）,2022(01):25-32
A类：
infiammatory,briefiy,infiammation
B类：
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AB值：
0.531365
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