Liver diseases and their co-morbidities represent a major public health problem.Owing to its progressive pathogenesis and lack of effective treatment,liver disease has become one of the most important causes of death worldwide.Traditional Chinese medicine(TCM)has potential advantages in the prevention and treatment of liver diseases,including high safety,remarkable curative effects,and low toxicity and side effects.In 2021,TCM extracts and their derivatives,TCM compounds,and ethnic medicines showed good efficacy in the treatment of liver diseases.The main mechanisms and representative drugs of TCM can be summarized by the use of amygdalin,dicoumarol,quercetin,and ancient ephedrine decoction to treat hepatitis by inhibiting viral replication,as well as the use of Gentianae Radix,lupeol,Zornia diphylla(L.)Pers.,and Chinese patent medicine Liuwei Wuling tablet to alleviate acute liver injury by improving oxidative stress and inflammatory responses in the body.In the treatment of alcoholic liver disease and metabolic-associated fatty liver disease,the mechanism of TCM is the inhibition of oxidative stress,improving metabolism,regulating intestinal microflora,and enhancing intestinal barrier function.The representative TCM for alcoholic liver disease includes astragaloside,puerarin,patchouli alcohol,and Mori Fructus polysaccharide,while those for metabolic-associated fatty liver disease include saikosaponin,dehydroabietic acid,hesperetin,berberine,and Panax Notoginseng saponins.Additionally,germacrone,forsythin,geniposide,and protocatechuic acid can inhibit the activation or migration of stellate cells and improve liver fibrosis.Toosendanin,paeoniflorin,chrysin,and the classical prescription Huanglian decoction can significantly inhibit the proliferation of liver cancer cells and promote their apoptosis for the treatment of hepatocellular carcinoma.The activation of the farnesol X receptor pathway can improve bile metabolism in the liver,thus,significantly alleviating cholestatic liver disease.Its representative drugs include the TCM extracts pterostilbene and arbutin.In this review,we summarize the advances made in research on TCM used in the treatment of liver diseases in 2021,providing a reference for further development of TCM for the prevention and treatment of liver diseases.

Jun-Yu Luo;Jia-Bao Liao;Yu-Ming Wang;Jie Zhao;Xue-Hua Xie;Fei Qu;Xi-Xing Fang;Wei-Bo Wen;Shu-Quan Lyu

Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing 314033,China;Tianjin University of Traditional Chinese Medicine,Tianjin 300000,China;Changchun University of Traditional Chinese Medicine,Changchun 130117,China;Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province,Cangzhou 061001,China

传统医学研究（英文版）

[1]Jun-Yu Luo;Jia-Bao Liao;Yu-Ming Wang;Jie Zhao;Xue-Hua Xie;Fei Qu;Xi-Xing Fang;Wei-Bo Wen;Shu-Quan Lyu-.Advances in traditional Chinese medicine for liver disease therapy in 2021)[J].传统医学研究（英文版）,2022(06):92-109

dicoumarol,ephedrine,Gentianae,Zornia,diphylla,Liuwei,patchouli,dehydroabietic,Notoginseng,germacrone,forsythin,Toosendanin,chrysin,farnesol

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