典型文献
Validation of the predictive accuracy of "clinical + morphology nomogram" for the rebleeding risk of ruptured intracranial aneurysms after admission
文献摘要：
Background::Rebleeding can cause a catastrophic outcome after aneurysmal subarachnoid hemorrhage. A clinical + morphology nomogram was promoted in our previous study to assist in discriminating the rupture intracranial aneurysms (RIAs) with a high risk of rebleeding. The aim of this study was to validate the predictive accuracy of this nomogram model.Method::The patients with RIAs in two medical centers from December 2020 to September 2021 were retrospectively reviewed, whose clinical and morphological parameters were collected. The Cox regression model was employed to identify the risk factors related to rebleeding after their admission. The predicting accuracy of clinical + morphological nomogram, ELAPSS score and PHASES score was compared based on the area under the curves (AUCs).Results::One hundred thirty-eight patients with RIAs were finally included in this study, 20 of whom suffering from rebleeding after admission. Hypertension (hazard ratio (HR), 2.54; a confidence interval of 95% (CI), 1.01-6.40;
P = 0.047), bifurcation (HR, 3.88; 95% CI, 1.29-11.66;
P = 0.016), and AR (HR, 2.68; 95% CI, 1.63-4.41;
P < 0.001) were demonstrated through Cox regression analysis as the independent risk factors for rebleeding after admission. The clinical + morphological nomogram had the highest predicting accuracy (AUC, 0.939,
P < 0.01), followed by the bifurcation (AUC, 0.735,
P = 0.001), AR (AUC, 0.666,
P = 0.018), and ELAPSS score (AUC, 0.682,
P = 0.009). Hypertension (AUC, 0.693,
P = 0.080) or PHASES score (AUC, 0.577,
P = 0.244) could not be used to predict the risk of rebleeding after admission. The calibration curve for the probability of rebleeding showed a good agreement between the prediction through clinical + morphological nomogram and actual observation.
Conclusion::Hypertension, bifurcation site, and AR were independent risk factors related to the rebleeding of RIAs after admission. The clinical + morphological nomogram could help doctors to identify the high-risk RIAs with a high predictive accuracy.
文献关键词：
Intracranial aneurysms;Rupture;Rebleeding;Morphology;Predicting model
中图分类号：
作者姓名：
Sui Jianfei;Wang Nuochuan;Jiang Pengjun;Wu Jun;Wang Qingzhen;Yuan Qiaolin;He Hongwei
作者机构：
Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070, China;Department of Transfusion, Beijing Tiantan Hospital, Capital Medical University, No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070, China;Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070, China;China National Clinical Research Center for Neurological Diseases, Beijing, People’s Republic of China;Department of Neurointervention, Beijing Tiantan Hospital, Capital Medical University, No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070, China
文献出处：
引用格式：
[1]Sui Jianfei;Wang Nuochuan;Jiang Pengjun;Wu Jun;Wang Qingzhen;Yuan Qiaolin;He Hongwei-.Validation of the predictive accuracy of "clinical + morphology nomogram" for the rebleeding risk of ruptured intracranial aneurysms after admission)[J].中华神经外科杂志（英文）,2022(03):143-150
A类：
rebleeding,Rebleeding,RIAs,ELAPSS,PHASES
B类：
Validation,predictive,accuracy,clinical,morphology,nomogram,risk,ruptured,intracranial,aneurysms,after,admission,Background,can,cause,catastrophic,outcome,aneurysmal,subarachnoid,hemorrhage,was,promoted,our,previous,study,assist,discriminating,aim,this,validate,model,Method,patients,two,medical,centers,from,December,September,were,retrospectively,reviewed,whose,morphological,parameters,collected,Cox,regression,employed,identify,factors,related,their,predicting,score,compared,area,under,curves,AUCs,Results,One,hundred,thirty,eight,finally,included,whom,suffering,Hypertension,hazard,confidence,interval,bifurcation,demonstrated,through,analysis,independent,had,highest,followed,by,could,not,used,calibration,probability,showed,good,agreement,between,prediction,actual,observation,Conclusion,site,help,doctors,Intracranial,Rupture,Morphology,Predicting
AB值：
0.404022
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