典型文献
Exploratory COVID-19 death risk score based on basic laboratory tests and physiological clinical measurements
文献摘要：
BACKGROUND: In the event of a sudden shortage of medical resources, a rapid, simple, and accurate prediction model is essential for the 30-day mortality rate of patients with COVID-19.METHODS: This retrospective study compared the characteristics of the survivals and non-survivals of 278 patients with COVID-19. Logistic regression analysis was performed to obtain the "COVID-19 death risk score" (CDRS) model. Using the area under the receiver operating characteristic (AUROC) curve and Hosmer-Lemeshow goodness-of-fit test, discrimination and calibration were assessed. Internal validation was conducted using a regular bootstrap method. RESULTS: A total of 63 (22.66％) of 278 included patients died. The logistic regression analysis revealed that high-sensitivity C-reactive protein (hsCRP; odds ratio [OR]=1.018), D-dimer (OR=1.101), and respiratory rate (RR; OR=1.185) were independently associated with 30-day mortality. CDRS was calculated as follows: CDRS=?10.245+(0.022×hsCRP)+(0.172×D-dimer)+(0.203×RR). CDRS had the same predictive effect as the sequential organ failure assessment (SOFA) and "confusion, uremia, respiratory rate, blood pressure, and age over 65 years" (CURB-65) scores, with AUROCs of 0.984 for CDRS, 0.975 for SOFA, and 0.971 for CURB-65, respectively. And CDRS showed good calibration. The AUROC through internal validations was 0.980 (95％ confidence interval [CI]: 0.965–0.995). Regarding the clinical value, the decision curve analysis of CDRS showed a net value similar to that of CURB-65 in this cohort. CONCLUSION: CDRS is a novel, efficient and accurate prediction model for the early identification of COVID-19 patients with poor outcomes. Although it is not as advanced as the other models, CDRS had a similar performance to that of SOFA and CURB-65.
文献关键词：
中图分类号：
作者姓名：
Gui-ying Dong;Fei-fei Jin;Qi Huang;Chun-bo Wu;Ji-hong Zhu;Tian-bing Wang
作者机构：
Emergency Department,Peking University People's Hospital,Beijing 100044,China;Trauma Center,Peking University People's Hospital,Key Laboratory of Trauma and Neural Regeneration(Peking University),Ministry of Education,Beijing100044,China;Department of Endocrinology and Metabolism,Peking University People's Hospital,Beijing100044,China
文献出处：
引用格式：
[1]Gui-ying Dong;Fei-fei Jin;Qi Huang;Chun-bo Wu;Ji-hong Zhu;Tian-bing Wang-.Exploratory COVID-19 death risk score based on basic laboratory tests and physiological clinical measurements)[J].世界急诊医学杂志（英文）,2022(06):453-458
A类：
survivals,245+,uremia,AUROCs
B类：
Exploratory,death,risk,basic,laboratory,tests,physiological,clinical,measurements,BACKGROUND,event,sudden,shortage,medical,resources,rapid,simple,accurate,prediction,essential,day,mortality,patients,METHODS,This,retrospective,study,compared,characteristics,regression,analysis,was,performed,obtain,CDRS,Using,area,under,receiver,operating,curve,Hosmer,Lemeshow,goodness,fit,discrimination,calibration,were,assessed,Internal,conducted,using,regular,bootstrap,method,RESULTS,total,included,died,logistic,revealed,that,high,sensitivity,reactive,protein,hsCRP,odds,dimer,respiratory,RR,independently,associated,calculated,follows,had,same,predictive,effect,sequential,organ,failure,assessment,SOFA,confusion,blood,pressure,over,years,CURB,scores,respectively,And,showed,through,internal,validations,confidence,interval,Regarding,value,decision,net,similar,this,cohort,CONCLUSION,novel,efficient,early,identification,poor,outcomes,Although,not,advanced,other,models,performance
AB值：
0.522855
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