典型文献
Usefulness of the CONUT index upon hospital admission as a potential prognostic indicator of COVID-19 health outcomes
文献摘要：
Background::In-hospital mortality in patients with coronavirus disease 2019 (COVID-19) is high. Simple prognostic indices are needed to identify patients at high-risk of COVID-19 health outcomes. We aimed to determine the usefulness of the CONtrolling NUTritional status (CONUT) index as a potential prognostic indicator of mortality in COVID-19 patients upon hospital admission.Methods::Our study design is of a retrospective observational study in a large cohort of COVID-19 patients. In addition to descriptive statistics, a Kaplan-Meier mortality analysis and a Cox regression were performed, as well as receiver operating curve (ROC).Results::From February 5, 2020 to January 21, 2021, there was a total of 2969 admissions for COVID-19 at our hospital, corresponding to 2844 patients. Overall, baseline (within 4 days of admission) CONUT index could be scored for 1627 (57.2%) patients. Patients’ age was 67.3 ± 16.5 years and 44.9% were women. The CONUT severity distribution was: 194 (11.9%) normal (0-1); 769 (47.2%) light (2-4); 585 (35.9%) moderate (5-8); and 79 (4.9%) severe (9-12). Mortality of 30 days after admission was 3.1% in patients with normal risk CONUT, 9.0% light, 22.7% moderate, and 40.5% in those with severe CONUT (
P < 0.05). An increased risk of death associated with a greater baseline CONUT stage was sustained in a multivariable Cox regression model (
P < 0.05). An increasing baseline CONUT stage was associated with a longer duration of admission, a greater requirement for the use of non-invasive and invasive mechanical ventilation, and other clinical outcomes (all
P < 0.05). The ROC of CONUT for mortality had an area under the curve (AUC) and 95% confidence interval of 0.711 (0.676-0746).
Conclusion::The CONUT index upon admission is potentially a reliable and independent prognostic indicator of mortality and length of hospitalization in COVID-19 patients.
文献关键词：
Admission;Clinical risk;CONUT;COVID-19;Prognosis;Score
中图分类号：
作者姓名：
Bengelloun Adrián K.;Ortega Guillermo J.;Ancochea Julio;Sanz-Garcia Ancor;Rodríguez-Serrano Diego A.;Fernández-Jiménez Guillermo;Girón Rosa;ávalos Elena;Soriano Joan B.;de Ulíbarri J. Ignacio
作者机构：
Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain;Unidad de Análisis de Datos, Instituto de Investigación Sanitaria del Hospital de la Princesa, Madrid, Spain;Servicios de Neumología, Admisión y Documentación Clínica, Cuidados Intensivos y Nutrición y Dietética; Hospital Universitario de La Princesa, Madrid, Spain;Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Espa?a, Spain
文献出处：
引用格式：
[1]Bengelloun Adrián K.;Ortega Guillermo J.;Ancochea Julio;Sanz-Garcia Ancor;Rodríguez-Serrano Diego A.;Fernández-Jiménez Guillermo;Girón Rosa;ávalos Elena;Soriano Joan B.;de Ulíbarri J. Ignacio-.Usefulness of the CONUT index upon hospital admission as a potential prognostic indicator of COVID-19 health outcomes)[J].中华医学杂志（英文版）,2022(02):187-193
A类：
CONtrolling,NUTritional
B类：
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AB值：
0.467343
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