典型文献
Prognostic nomogram incorporating radiological features for predicting overall survival in patients with AIDS-related non-Hodgkin lymphoma
文献摘要：
Background::Acquired immune deficiency syndrome (AIDS)-related non-Hodgkin lymphoma (AR-NHL) is a high-risk factor for morbidity and mortality in patients with AIDS. This study aimed to determine the prognostic factors associated with overall survival (OS) and to develop a prognostic nomogram incorporating computed tomography imaging features in patients with acquired immune deficiency syndrome-related non-Hodgkin lymphoma (AR-NHL).Methods::A total of 121 AR-NHL patients between July 2012 and November 2019 were retrospectively reviewed. Clinical and radiological independent predictors of OS were confirmed using multivariable Cox analysis. A prognostic nomogram was constructed based on the above clinical and radiological factors and then provided optimum accuracy in predicting OS. The predictive accuracy of the nomogram was determined by Harrell C-statistic. Kaplan-Meier survival analysis was used to determine median OS. The prognostic value of adjuvant therapy was evaluated in different subgroups.Results::In the multivariate Cox regression analysis, involvement of mediastinal or hilar lymph nodes, liver, necrosis in the lesions, the treatment with chemotherapy, and the CD4 ≤100 cells/μL were independent risk factors for poor OS (all
P < 0.050). The predictive nomogram based on Cox regression has good discrimination (Harrell C-index = 0.716) and good calibration (Hosmer-Lemeshow test,
P = 0.620) in high- and low-risk groups. Only patients in the high-risk group who received adjuvant chemotherapy had a significantly better survival outcome.
Conclusion::A survival-predicting nomogram was developed in this study, which was effective in assessing the survival outcomes of patients with AR-NHL. Notably, decision-making of chemotherapy regimens and more frequent follow-up should be considered in the high-risk group determined by this model.
文献关键词：
Lymphoma;AIDS-related AR-NHL;Computed tomography;Prognosis;Nomogram
中图分类号：
作者姓名：
Li Xueqin;Pan Ziang;Wang Xing;Hu Tianli;Ye Wen;Jiang Dongmei;Shen Wen;Liu Jinxin;Shi Yuxin;Xia Shuang;Li Hongjun
作者机构：
Radiological Department, Beijing You'an Hospital Affiliated of Capital Medical University, Beijing 100069, China;Neurological Department, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China;Radiological Department, The Eighth People's Hospital of Guangzhou, Guangzhou, Guangdong 510060, China;Radiological Department, Shanghai Public Health Clinical Center, Affiliated of Fudan University, Shanghai 201058, China;Radiation Department, Tianjin First Central Hospital, Tianjin 300170, China;Radiological Department, Tianjin First Central Hospital, Tianjin 300192, China
文献出处：
引用格式：
[1]Li Xueqin;Pan Ziang;Wang Xing;Hu Tianli;Ye Wen;Jiang Dongmei;Shen Wen;Liu Jinxin;Shi Yuxin;Xia Shuang;Li Hongjun-.Prognostic nomogram incorporating radiological features for predicting overall survival in patients with AIDS-related non-Hodgkin lymphoma)[J].中华医学杂志（英文版）,2022(01):70-78
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B类：
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AB值：
0.500014
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