典型文献
Adjunctive sepsis therapy with aminophylline (STAP): a randomized controlled trial
文献摘要：
Background::Sepsis is a serious disease caused by infection. Aminophylline has anti-asthma and anti-inflammatory effects. We aimed to explore the safety and effect of aminophylline in sepsis.Methods::We conducted a clinical randomized controlled trial involving 100 patients diagnosed with sepsis within 48 h after intensive care unit (ICU) admission in two sites. All patients were randomized in a 1:1 ratio to receive standard therapy with or without aminophylline. The primary clinical outcome was all-cause mortality at 28 days.Results::From September 27, 2018 to February 12, 2020, we screened 277 septic patients and eventually enrolled 100 patients, with 50 assigned to the aminophylline group and 50 to the usual-care group. At 28 days, 7 of 50 patients (14.0%) in the aminophylline group had died, compared with 16 of 50 (32.0%) in the usual-care group (
P = 0.032). Cox regression showed that the aminophylline group had a lower hazard of death (hazard ratio = 0.312, 95% confidence interval: 0.129-0.753). Compared with the usual-care group, patients in the aminophylline group had a longer survival time (
P = 0.039 by the log-rank test). The effects of aminophylline on vasopressor dose, oxygenation index, and sequential organ failure assessment score were time-dependent with treatment. There were no significant differences in total hospitalization days, ICU hospitalization days, and rates of serious adverse events (all
P > 0.05). No adverse events were observed in the trial.
Conclusions::Aminophylline as an adjunct therapy could significantly reduce the risk of death and prolong the survival time of patients with sepsis.Trial registration::ChiCTR.org.cn, ChiCTR1800019173.
文献关键词：
Aminophylline;Mortality;Randomized controlled trial;Sepsis
中图分类号：
作者姓名：
Zhang Ruifang;Liu Huan;Dai Dongmei;Ding Xianfei;Wang Dong;Wang Yan;Shi Xuexiu;Zhang Shuguang;Duan Xiaoguang;Wang Haixu;Luo Yonggang;Liu Shaohua;Han Bing;Zhang Xiaojuan;Fang Yu;Yang Jing;Xu Wangbin;Sun Tongwen
作者机构：
General ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Henan Engineering Research Center for Critical Care Medicine, Zhengzhou, Henan 450052, China;Department of Intensive Care Unit, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China;Precision Medicine Monitoring Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
文献出处：
引用格式：
[1]Zhang Ruifang;Liu Huan;Dai Dongmei;Ding Xianfei;Wang Dong;Wang Yan;Shi Xuexiu;Zhang Shuguang;Duan Xiaoguang;Wang Haixu;Luo Yonggang;Liu Shaohua;Han Bing;Zhang Xiaojuan;Fang Yu;Yang Jing;Xu Wangbin;Sun Tongwen-.Adjunctive sepsis therapy with aminophylline (STAP): a randomized controlled trial)[J].中华医学杂志（英文版）,2022(23):2843-2850
A类：
Adjunctive,aminophylline,Aminophylline,ChiCTR1800019173
B类：
sepsis,therapy,STAP,randomized,controlled,trial,Background,Sepsis,serious,disease,caused,by,infection,has,anti,asthma,inflammatory,effects,We,aimed,explore,safety,Methods,conducted,clinical,involving,patients,diagnosed,within,after,intensive,care,unit,ICU,admission,two,sites,All,were,receive,standard,without,primary,outcome,was,mortality,days,Results,From,September,February,screened,septic,eventually,enrolled,assigned,group,usual,At,had,died,compared,Cox,regression,showed,that,lower,hazard,death,confidence,interval,Compared,longer,survival,log,rank,test,vasopressor,dose,oxygenation,sequential,organ,failure,assessment,score,dependent,treatment,There,differences,total,hospitalization,rates,adverse,events,No,observed,Conclusions,adjunct,could,significantly,reduce,risk,prolong,Trial,registration,cn,Mortality,Randomized
AB值：
0.481792
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
