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典型文献
Safety and immunogenicity of COVID-19 vaccination among liver transplant recipients in China
文献摘要:
To the Editor: During the ongoing coronavirus disease 2019(COVID-19)pan-demic globally,patients with chronic liver diseases(CLD),par-ticularly cirrhosis,hepatobiliary malignancies,candidates for liver transplantation(LT),and immunosuppressed LT recipients appear to be at increased risk of infections,which leads to an increase in mortality[1-6].Apart from physical distancing,quarantine and isolation,vaccination is crucial for the restraining of the epidemic and the protection from severe acute respiratory syndrome coron-avirus 2(SARS-CoV-2)infection and aggravation of COVID-19[7,8].A recent prospective,multicenter,open-label study in China has demonstrated the safety of inactivated whole-virion SARS-CoV-2 vaccines in patients with CLD;however,these patients had de-creased response(76.7%-78.9%)to SARS-CoV-2 vaccines compared with healthy subjects(90.3%),which might be associated with the impairment in immunity in the population with CLD[9].This raises the concern in the safety and immunogenicity of COVID-19 vaccination among LT recipients in China since this population may have more suppressed immunity[8,10,11].Herein,we prelimi-nary investigated the influence of COVID-19 vaccination on general safety,graft function,host immunogenicity of vaccination among LT recipients in a large transplantation center in China.
文献关键词:
作者姓名:
Qiu-Ju Tian;Man Xie;Ji-Tao Wang;Yi Wang;Bei Zhang;Jin-Zhen Cai;Xiao-Long Qi;Wei Rao
作者机构:
Division of Hepatology,Liver Disease Center,The Affiliated Hospital of Qingdao University,Qingdao 266000,China;Department of Organ Transplantation,The Affiliated Hospital of Qingdao University,Qingdao 266000,China;Department of Gastroenterology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China;CHESS-COVID-19 Group,Xingtai People's Hospital,Xingtai 054000,China;Department of Clinical Laboratory,The Affiliated Hospital of Qingdao University,Qingdao 266000,China;Department of Immunology,Qingdao University Medical College,Qingdao 266000,China;CHESS Center,Institute of Portal Hypertension,The First Hospital of Lanzhou University,Lanzhou 730000,China
引用格式:
[1]Qiu-Ju Tian;Man Xie;Ji-Tao Wang;Yi Wang;Bei Zhang;Jin-Zhen Cai;Xiao-Long Qi;Wei Rao-.Safety and immunogenicity of COVID-19 vaccination among liver transplant recipients in China)[J].国际肝胆胰疾病杂志(英文版),2022(06):605-608
A类:
During,prelimi
B类:
Safety,immunogenicity,vaccination,among,liver,recipients,China,To,Editor,ongoing,coronavirus,pan,globally,patients,chronic,diseases,CLD,ticularly,cirrhosis,hepatobiliary,malignancies,candidates,transplantation,LT,immunosuppressed,appear,increased,risk,infections,which,leads,mortality,Apart,from,physical,distancing,quarantine,isolation,crucial,restraining,epidemic,protection,severe,acute,respiratory,syndrome,SARS,CoV,aggravation,recent,prospective,multicenter,open,label,study,has,demonstrated,safety,inactivated,whole,virion,vaccines,however,these,had,response,compared,healthy,subjects,might,associated,impairment,immunity,population,This,raises,concern,since,this,may,have,more,Herein,nary,investigated,influence,general,graft,function,host,large
AB值:
0.533238
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