典型文献
Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell transplantation:PAH risk score
文献摘要：
Skin and soft tissue infections(SSTIs)refer to infections involving the skin,subcutaneous tissue,fascia,and muscle.In transplant populations with hematological malignancies,an immunocompromised status and the routine use of immunosuppressants increase the risk of SSTIs greatly.However,to date,the profiles and clinical outcomes of SSTIs in hematopoietic stem cell transplantation(HSCT)patients remain unclear.This study included 228 patients(3.67％)who developed SSTIs within 180 days after allogeneic HSCT from January 2004 to December 2019 in Peking University People's Hospital.The overall annual survival rate was 71.5％.We compared the differences between survivors and non-survivors a year after transplant and found that primary platelet graft failure(PPGF),comorbidities of acute kidney injury(AKI),and hospital-acquired pneumonia(HAP)were independent risk factors for death in the study population.A PPGF-AKI-HAP risk stratification system was established with a mortality risk score of 1xPPGF+1xAKI+1xHAP.The areas under the curves of internal and external validation were 0.833(95％CI 0.760-0.906)and 0.826(95％CI 0.715-0.937),respectively.The calibration plot revealed the high consistency of the estimated risks,and decision curve analysis showed considerable net benefits for patients.
文献关键词：
中图分类号：
作者姓名：
Shan Chong;Yun He;Yejun Wu;Peng Zhao;Xiaolu Zhu;Fengrong Wang;Yuanyuan Zhang;Xiaodong Mo;Wei Han;Jingzhi Wang;Yu Wang;Huan Chen;Yuhong Chen;Xiangyu Zhao;Yingjun Chang;Lanping Xu;Kaiyan Liu;Xiaojun Huang;Xiaohui Zhang
作者机构：
Peking University People s Hospital,Peking University Institute of Hematology,Beijing 100044,China;Collaborative Innovation Center of Hematology,Peking University,Beijing 100044,China;Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Beijing 100044,China;National Clinical Research Center for Hematologic Disease,Beijing 100044,China
文献出处：
引用格式：
[1]Shan Chong;Yun He;Yejun Wu;Peng Zhao;Xiaolu Zhu;Fengrong Wang;Yuanyuan Zhang;Xiaodong Mo;Wei Han;Jingzhi Wang;Yu Wang;Huan Chen;Yuhong Chen;Xiangyu Zhao;Yingjun Chang;Lanping Xu;Kaiyan Liu;Xiaojun Huang;Xiaohui Zhang-.Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell transplantation:PAH risk score)[J].医学前沿,2022(06):957-968
A类：
immunosuppressants,PPGF,1xPPGF+1xAKI+1xHAP
B类：
Risk,stratification,system,skin,soft,tissue,infections,after,allogeneic,hematopoietic,cell,transplantation,PAH,score,Skin,SSTIs,refer,involving,subcutaneous,fascia,muscle,In,populations,hematological,malignancies,immunocompromised,status,routine,use,increase,greatly,However,date,profiles,clinical,outcomes,HSCT,patients,remain,unclear,This,study,included,who,developed,within,days,from,January,December,Peking,University,People,Hospital,overall,annual,survival,rate,was,We,compared,differences,between,survivors,year,found,that,primary,platelet,graft,failure,comorbidities,acute,kidney,injury,hospital,acquired,pneumonia,were,independent,factors,death,established,mortality,areas,under,curves,internal,external,validation,respectively,calibration,plot,revealed,high,consistency,estimated,risks,decision,analysis,showed,considerable,net,benefits
AB值：
0.595168
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
