Background::The onset and clinical presentation of systemic lupus erythematosus (SLE) are sex-related. Few studies have investigated the distinctions in clinical characteristics and treatment preferences in male and female SLE patients in the initial cohort. This study aimed to improve the understanding of Chinese SLE patients by characterizing the different sexes of SLE patients in the inception cohort.Methods::Based on the initial patient cohort established by the Chinese SLE Treatment and Research Group, a total of 8713 patients (795 men and 7918 women) with newly diagnosed SLE were enrolled between April 2009 and March 2021. Of these, 2900 patients (347 men and 2553 women) were eligible for lupus nephritis (LN). A cross-sectional analysis of the baseline demographic characteristics, clinical manifestations, laboratory parameters, organ damage, initial treatment regimens, and renal pathology classification was performed according to sex.Results::In the SLE group, as compared to female patients, male patients had a later age of onset (male vs. female: 37.0 ± 15.8 years vs. 35.1 ± 13.7 years, P = 0.006) and a higher SLE International Collaborative Clinic/American College of Rheumatology damage index score (male vs. female: 0.47 ± 1.13 vs. 0.34 ± 0.81, P = 0.015), LN (male vs. female: 43.6% vs. 32.2%, P < 0.001), fever (male vs. female: 18.0% vs. 14.6%, P = 0.010), thrombocytopenia (male vs. female: 21.4% vs. 18.5%, P = 0.050), serositis (male vs. female: 14.7% vs. 11.7%, P= 0.013), renal damage (male vs. female: 11.1% vs. 7.4%, P < 0.001), and treatment with cyclophosphamide (CYC) ( P < 0.001). The frequency of leukopenia (male vs. female: 20.5% vs. 25.4%, P = 0.002) and arthritis (male vs. female: 22.0% vs. 29.9%, P < 0.001) was less in male patients with SLE. In LN, no differences were observed in disease duration, SLE Disease Activity Index score, renal biopsy pathological typing, or 24-h urine protein quantification among the sexes. In comparisons with female patients with LN, male patients had later onset ages ( P = 0.026), high serum creatinine ( P < 0.001), higher end-stage renal failure rates ( P = 0.002), musculoskeletal damage ( P = 0.023), cardiovascular impairment ( P = 0.009), and CYC use ( P = 0.001); while leukopenia ( P = 0.017), arthritis ( P = 0.014), and mycophenolate usage ( P = 0.013) rates were lower. Conclusions::Male SLE patients had more severe organ damage and a higher LN incidence compared with female SLE patients; therefore, they may require more aggressive initial treatment compared to female patients.

Systemic lupus erythematosus;Lupus nephritis;Sex;End-stage renal disease;Sex differences

Gui Yinli;Bai Wei;Xu Jian;Duan Xinwang;Zhan Feng;Zhao Chen;Jiang Zhenyu;Li Zhijun;Wu Lijun;Liu Shengyun;Yang Min;Wei Wei;Wang Ziqian;Zhao Jiuliang;Wang Qian;Leng Xiaomei;Tian Xinping;Li Mengtao;Zhao Yan;Zeng Xiaofeng;CSTAR co-authors

Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China;Department of Rheumatology, The People’s Hospital of Zhengzhou, Zhengzhou, Henan 450003, China;Department of Rheumatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China;Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China;Department of Rheumatology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China;Department of Rheumatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China;Department of Rheumatology, The Bethune First Hospital of Jilin University, Changchun, Jilin 130021, China;Department of Rheumatology, The Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China;Department of Rheumatology, The People’s Hospital of Xinjiang Autonomous Region, Urumqi, Xinjiang 830001, China;Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China;Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China;Department of Rheumatology, Tianjin Medical University General Hospital, Tianjin 300052, China

中华医学杂志（英文版）

[1]Gui Yinli;Bai Wei;Xu Jian;Duan Xinwang;Zhan Feng;Zhao Chen;Jiang Zhenyu;Li Zhijun;Wu Lijun;Liu Shengyun;Yang Min;Wei Wei;Wang Ziqian;Zhao Jiuliang;Wang Qian;Leng Xiaomei;Tian Xinping;Li Mengtao;Zhao Yan;Zeng Xiaofeng;CSTAR co-authors-.Sex differences in systemic lupus erythematosus (SLE): an inception cohort of the Chinese SLE Treatment and Research Group (CSTAR) registry XVII)[J].中华医学杂志（英文版）,2022(18):2191-2199

CSTAR,XVII,serositis

Sex,differences,systemic,lupus,erythematosus,SLE,inception,cohort,Chinese,Treatment,Research,Group,registry,Background,onset,clinical,presentation,related,Few,studies,have,investigated,distinctions,characteristics,treatment,preferences,female,patients,initial,This,study,aimed,improve,understanding,by,characterizing,different,sexes,Methods,Based,established,total,women,newly,diagnosed,were,enrolled,between,April,March,Of,these,eligible,nephritis,LN,cross,sectional,analysis,baseline,demographic,manifestations,laboratory,parameters,organ,damage,regimens,renal,pathology,classification,was,performed,according,Results,group,compared,had,later,years,higher,International,Collaborative,Clinic,American,College,Rheumatology,score,fever,thrombocytopenia,cyclophosphamide,CYC,frequency,leukopenia,arthritis,less,observed,disease,duration,Disease,Activity,Index,biopsy,pathological,typing,urine,protein,quantification,among,comparisons,ages,serum,creatinine,end,stage,failure,rates,musculoskeletal,cardiovascular,impairment,use,while,mycophenolate,usage,lower,Conclusions,Male,more,severe,incidence,therefore,they,may,require,aggressive,Systemic,Lupus,End

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