典型文献
Early versus delayed intervention in necrotizing acute pancreatitis complicated by persistent organ failure
文献摘要：
Background: Current guidelines for the treatment of patients with necrotizing acute pancreatitis (NAP) recommend that invasive intervention for pancreatic necrosis should be deferred to 4 or more weeks from disease onset to allow necrotic collections becoming "walled-off". However, for patients showing signs of clinical deterioration, especially those with persistent organ failure (POF), it is controversial whether this delayed approach should always be adopted. In this study, we aimed to assess the impact of differently timed intervention on clinical outcomes in a group of NAP patients complicated by POF.Methods: All NAP patients admitted to our hospital from January 2013 to December 2017 were screened for potential inclusion. They were divided into two groups based on the timing of initial interven- tion (within 4 weeks and beyond 4 weeks). All the data were extracted from a prospectively collected database. Results: Overall, 131 patients were included for analysis. Among them, 100 (76.3％) patients were in- tervened within 4 weeks and 31 (23.7％) underwent delayed interventions. As for organ failure prior to intervention, the incidences of respiratory failure, renal failure and cardiovascular failure were not signifi- cantly different between the two groups ( P > 0.05). The mortality was not significantly different between the two groups (35.0％ vs. 32.3％, P = 0.83). The incidences of new-onset multiple organ failure (8.0％ vs. 6.5％, P = 1.00), gastrointestinal fistula (29.0％ vs. 12.9％, P = 0.10) and bleeding (35.0％ vs. 35.5％, P = 1.00), and length of ICU (30.0 vs. 22.0 days, P = 0.61) and hospital stay (42.5 vs. 40.0 days, P = 0.96) were com- parable between the two groups. Conclusion: Intervention within 4 weeks did not worsen the clinical outcomes in NAP patients compli- cated by POF.
文献关键词：
中图分类号：
作者姓名：
He Zhang;Lin Gao;Wen-Jian Mao;Jie Yang;Jing Zhou;Zhi-Hui Tong;Lu Ke;Wei-Qin Li
作者机构：
Medical School of Southeast University,87 Dingjiaqiao,Nanjing 210009,China;Center of Severe Acute Pancreatitis(CSAP),Department of General Surgery,Jinling Hospital,Medical School of Southeast University,No.305 Zhongshan East Road,Nanjing 210002,China
文献出处：
引用格式：
[1]He Zhang;Lin Gao;Wen-Jian Mao;Jie Yang;Jing Zhou;Zhi-Hui Tong;Lu Ke;Wei-Qin Li-.Early versus delayed intervention in necrotizing acute pancreatitis complicated by persistent organ failure)[J].国际肝胆胰疾病杂志(英文版),2022(01):63-68
A类：
tervened,parable
B类：
Early,versus,delayed,necrotizing,acute,pancreatitis,complicated,by,persistent,organ,failure,Background,Current,guidelines,treatment,patients,NAP,recommend,that,invasive,pancreatic,necrosis,should,deferred,more,weeks,from,disease,onset,allow,necrotic,collections,becoming,walled,off,However,showing,signs,clinical,deterioration,especially,those,POF,controversial,whether,this,approach,always,adopted,study,aimed,assess,impact,differently,timed,outcomes,Methods,All,admitted,our,hospital,January,December,were,screened,potential,inclusion,They,divided,into,two,groups,timing,initial,within,beyond,extracted,prospectively,collected,database,Results,Overall,included,analysis,Among,them,underwent,interventions,prior,incidences,respiratory,renal,cardiovascular,not,between,mortality,was,significantly,new,multiple,gastrointestinal,fistula,bleeding,length,ICU,days,stay,Conclusion,Intervention,did,worsen
AB值：
0.507395
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
