典型文献
Transmission and mortality risk assessment of severe fever with thrombocytopenia syndrome in China: results from 11-years’ study
文献摘要：
Background::The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.Methods::Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011-2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk ( RR). Mortality risk factors were analyzed using a logistic regression model. Results::There were 35 SFTS clusters during 2011-2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%; χ 2 = 210.97, P < 0.05), with an RR of 16.61 [95% confidence interval ( CI): 10.23-26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%; χ 2= 6.40, P < 0.05), with an RR of 1.93 (95% CI: 1.11-3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio ( OR)= 1.385), 95% CI: 1.083-1.772, P= 0.009) and advanced age ( OR: 1.095, 95% CI: 1.031-1.163, P= 0.01). Conclusions::The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corpses, to prevent further transmission and mortality.
文献关键词：
Severe fever with thrombocytopenia syndrome;Cluster;Human-to-human transmission;Transmission risk;Secondary attack rate;Blood contact;Relative risk;Epidemiological characteristics;Mortality;China
中图分类号：
作者姓名：
Chen Qiulan;Yang Dong;Zhang Yanping;Zhu Mantong;Chen Ning;Yushan Zainawudong
作者机构：
Key Laboratory of Surveillance and Early-Warning on Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing, China;Changsha Center for Disease Control and Prevention, Changsha, China;School of Public Health, Guangxi Medical University, Nanning, China;Chinese Center for Disease Control and Prevention, Changbai Road, Changping, Beijing 102206, China
文献出处：
引用格式：
[1]Chen Qiulan;Yang Dong;Zhang Yanping;Zhu Mantong;Chen Ning;Yushan Zainawudong-.Transmission and mortality risk assessment of severe fever with thrombocytopenia syndrome in China: results from 11-years’ study)[J].贫困所致传染病（英文）,2022(05):30-40
A类：
bloody,corpses
B类：
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AB值：
0.495273
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