Background::There are insufficient data regarding the impact of acute respiratory distress syndrome related to coronavirus disease 2019 (C-ARDS) - caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - on health-related quality of life (HRQoL) and the occurrence of stress-related disorders in coronavirus disease 2019 (COVID-19) intensive care unit (ICU) survivors. The aim of this study is to assess HRQoL and the occurrence of stress-related disorders (acute stress disorder [ASD] and post-traumatic stress disorder [PTSD]) in C-ARDS ICU survivors at 1 and 6 months following hospital discharge.Methods::This prospective observational study included 90 patients treated for C-ARDS between March and May 2020 in the ICU and discharged alive from the hospital. All patients included in the study were contacted by telephone 1 month and 6 months post-hospital discharge to assess the presence of symptoms of stress-related disorders and HRQoL using the 8-item Treatment Outcome Post-traumatic Stress Disorder scale (TOP-8) and 36-item Short Form survey (SF-36). We performed univariate analyses to evaluate differences between patients who developed stress and those who did not. We also compared SF-36 scores in our sample with data from the general Spanish population and from cohorts of non-C-ARDS and severe acute respiratory syndrome coronavirus-1 (SARS-CoV-1) survivors.Results::There are 24.1% of patients showed symptoms of ASD; in 13.5% of cases the symptoms persisted 6 months later. Risk factors for the development of symptoms of ASD and PTSD are younger age, female sex, obesity, a previously diagnosed psychiatric disease and disease severity at ICU admission ( P < 0.05). HRQoL was greatly affected by C-ARDS; however, there was improvement on all scales of the SF-36 at the 6-month follow-up ( P < 0.05). The mean SF-36 score of our sample was higher than those previously reported in non-C-ARDS survivors ( P < 0.05) for physical functioning (78.0 vs. 52.0), role functioning/physical (51.0 vs. 31.0), bodily pain (76.1 vs. 57.0), vitality (58.6 vs. 48.0), social function (72.6 vs. 63.0) and role emotional (77.4 vs. 55.0), except on the general health scale. C-ARDS survivors also scored better than SARS-CoV-1 survivors on all scales except for body pain ( P < 0.05). Conclusions::The impact of C-ARDS on HRQoL is substantial, with frequent occurrence of PTSD symptoms. Patients are heavily affected in all areas of health in the first month of post-hospital discharge but show a dramatic improvement within 6 months, especially in terms of physical health.

COVID-19;Post-intensive care syndrome;Respiratory distress syndrome, Adult;Health-related quality of life;Post-traumatic stress disorder

Gil Diego;Tiscar Carlos;Gómez Maria;Felices Javier;Gajate Luis;Fernandez Patricia;Pesta?a David;Bardi Tommaso

Department of Anaesthesiology and Critical Care, Ramón y Cajal Hospital, 28034 Madrid, Spain;Department of Psychology, Ramón y Cajal Hospital, 28034 Madrid, Spain

重症医学（英文）

[1]Gil Diego;Tiscar Carlos;Gómez Maria;Felices Javier;Gajate Luis;Fernandez Patricia;Pesta?a David;Bardi Tommaso-.Health-related quality of life and stress-related disorders in COVID-19 ICU survivors: Are they worse than with other causes of ARDS?)[J].重症医学（英文）,2022(02):103-109

Health,related,quality,life,disorders,ICU,survivors,Are,they,worse,than,other,causes,ARDS,Background,There,insufficient,data,regarding,impact,acute,respiratory,distress,syndrome,coronavirus,disease,caused,by,severe,SARS,CoV,health,HRQoL,occurrence,intensive,care,unit,aim,this,study,assess,ASD,post,traumatic,PTSD,months,following,hospital,Methods,This,prospective,observational,included,patients,treated,between,March,May,discharged,alive,from,All,were,contacted,telephone,presence,symptoms,using,item,Treatment,Outcome,Post,Stress,Disorder,TOP,Short,Form,survey,SF,We,performed,univariate,analyses,evaluate,differences,who,developed,those,did,not,also,compared,scores,our,sample,general,Spanish,population,cohorts,Results,showed,cases,persisted,later,Risk,factors,development,younger,age,female,sex,obesity,previously,diagnosed,psychiatric,severity,admission,was,greatly,affected,however,there,improvement,scales,up,mean,higher,reported,physical,functioning,role,bodily,pain,vitality,social,emotional,except,scored,better,body,Conclusions,substantial,frequent,Patients,heavily,areas,first,but,dramatic,within,especially,terms,Respiratory,Adult

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