BACKGROUND It has previously been described that fall-associated injuries including fractures are commonly observed among patients with bradyarrhythmia. However, knowledge on the risk of pacemaker implantation after admission due to femur fracture from large population-based epidemiologic data is lacking. Therefore, we investigated the risk of pacemaker implanta-tion following femur fracture in patients with and without a history of previous syncope. METHODS All patients with femur fracture between 2005-2017 were identified using the Danish Nationwide Patient Registry. Among these, patients already having a pacemaker were excluded. Primary outcome was one-year risk of pacemaker implanta-tion and secondary outcome was one-year all-cause mortality. Multivariable logistic regression was used to obtain absolute and relative risks of the study endpoint in relation to patients with versus without history of syncope and standardized to the age, sex, selected comorbidity and pharmacotherapy distribution of all patients. RESULTS Of 93,093 patients with femur fracture, 5508 (5.9％) had a history of syncope within five years. Patients with prior syn-cope were slightly older (84 vs. 83 years), more often male (33.6％ vs. 29.4％), and had more often comorbidities relative to those without history of syncope. All-cause mortality was significantly higher among those with previous history of syncope com-pared to those without previous syncope (29.9％ vs. 28.6％, P = 0.021). The relative mortality risk was 1.05 (95％ CI: 1.01?1.09, P =0.021). A total of 695 (0.8％) patients underwent pacemaker implantation within 5 years following femur fracture, and a signific-antly higher proportion of patients with syncope had a pacemaker implanted within one year (1.6％ vs. 0.7％, P < 0.001; relative risk, 2.01 [95％ CI: 1.55?2.46]). CONCLUSIONS In patients with femur fracture, a history of syncope was significantly associated with a higher one-year risk of pacemaker implantation.

Sara LK Clemmensen;Kristian Kragholm;Bhupendar Tayal;Christian Torp-Pedersen;S?ren Kold;Peter S?gaard;Sam Riahi

Department of Cardiology,Aalborg University Hospital,Aalborg,Denmark;Unit of Clinical Biostatistics and Epi-demiology,Aalborg University Hospital,Aalborg,Denmark;Department of Clinical Epidemiology,Aalborg University Hospital,Aalborg,Denmark;Department of Orthopedics,Aalborg University Hospital,Aalborg,Denmark;Depart-ment of Clinical Institute,Aalborg University Hospital,Aalborg,Denmark

老年心脏病学杂志（英文版）

[1]Sara LK Clemmensen;Kristian Kragholm;Bhupendar Tayal;Christian Torp-Pedersen;S?ren Kold;Peter S?gaard;Sam Riahi-.Risk of pacemaker implantation after femur fracture in patients with and without a history syncope: a Danish nationwide registry-based follow-up study)[J].老年心脏病学杂志（英文版）,2022(09):712-718

bradyarrhythmia,antly

Risk,pacemaker,implantation,after,femur,patients,without,history,syncope,Danish,nationwide,registry,up,study,BACKGROUND,It,has,previously,been,described,that,fall,associated,injuries,including,fractures,commonly,observed,among,However,knowledge,admission,due,from,large,population,epidemiologic,data,lacking,Therefore,investigated,following,METHODS,All,between,were,identified,using,Nationwide,Registry,Among,these,already,having,excluded,Primary,outcome,was,one,secondary,cause,mortality,Multivariable,logistic,regression,used,obtain,absolute,relative,risks,endpoint,relation,versus,standardized,age,sex,selected,comorbidity,pharmacotherapy,distribution,RESULTS,Of,had,within,five,years,Patients,prior,slightly,older,more,often,male,comorbidities,those,significantly,higher,pared,total,underwent,proportion,implanted,CONCLUSIONS,In

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