Emerging evidence has highlighted the role of gut microbiome in human health.However,the integrative role of gut microbiome and microbial metabolites in acute myocardial infarction(AMI)remains unclear.The current study profiles the microbial community through 16S rRNA gene sequencing and shotgun meta-genomic sequencing and measures fecal short-chain fatty acids and circulating choline pathway metab-olites among 117 new-onset AMI cases and 78 controls.Significant microbial alternations are observed in AMI patients compared with controls(P=0.001).The abundances of nine species(e.g.,Streptococcus salivarius and Klebsiella pneumoniae)are positively associated,and one species(Roseburia hominis)is inversely associated with AMI status and severity.A gut microbial score at disease onset is associated with the risk of major adverse cardiovascular events in 3.2 years(hazard ratio[95％Cl]:2.01[1.04-4.24])in AMI patients.The molar proportions of fecal acetate and butyrate are higher,and the circulating levels of choline and carnitine are lower in AMI patients than in controls.In addition,disease classifiers show that AMI cases and controls have a more distinct pattern in taxonomical composition than in pathways or metabolites.Our findings suggest that microbial composition and functional potentials are associated with AMI status and severity.

Chenglin Liu;Zhonghan Sun;Shalaimaiti Shali;Zhendong Mei;Shufu Chang;Hanjun Mo;Lili Xu;Yanni Pu;Huihui Guan;Guo-Chong Chen;Qibin Qi;Zhexue Quan;Ji Qi;Kang Yao;Yuxiang Dai;Yan Zheng;Junbo Ge

State Key Laboratory of Genetic Engineering,School of Life Sciences and Human Phenome Institute,Fudan University,Shanghai 200433,China;Ministry of Education Key Laboratory of Contemporary Anthropology,Fudan University,Shanghai 200433,China;Department of Cardiology,Shanghai Institute of Cardiovascular Disease,Zhongshan Hospital,Fudan University,1609 Xietu Road,Shanghai 200032,China;Department of Epidemiology and Population Health,Albert Einstein College of Medicine,Bronx,NY 10461,USA;Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering,Institute of Biodiversity Science,School of Life Sciences,Fudan University,Shanghai 200433,China

遗传学报

[1]Chenglin Liu;Zhonghan Sun;Shalaimaiti Shali;Zhendong Mei;Shufu Chang;Hanjun Mo;Lili Xu;Yanni Pu;Huihui Guan;Guo-Chong Chen;Qibin Qi;Zhexue Quan;Ji Qi;Kang Yao;Yuxiang Dai;Yan Zheng;Junbo Ge-.The gut microbiome and microbial metabolites in acute myocardial infarction)[J].遗传学报,2022(06):569-578

taxonomical

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