典型文献
Functional Proteomics Driven by Chemical and Computational Approaches
文献摘要：
Functional proteomics is a powerful approach to globally investigate protein functions and their bio-logical significance.Activity-based protein profiling(ABPP)has been widely applied to explore the activ-ity and ligandability of proteins in complex biological systems.Herein,we summarized our efforts in de-veloping chemical probes and chemical proteomic pipelines to identify protein targets of certain post-translational modifications(PTMs),covalent drugs,natural products and cellular metabolites.Furthermore,computer-aided proteomic strategies were developed to globally identify functional resi-dues including hyper-reactive cysteines,active sites of selenoproteins and proximal anchors for protein activation.
文献关键词：
中图分类号：
作者姓名：
Ying Chen;Wei Qin;Chu Wang
作者机构：
College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China;Beijing National Laboratory for Molecular Sciences,Peking University,Beijing 100871,China;Synthetic and Functional Biomolecules Center,Peking University,Beijing 100871,China;Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,Peking University,Beijing 100871,China;Peking-Tsinghua Center for Life Science,Peking University,Beijing 100871,China
文献出处：
引用格式：
[1]Ying Chen;Wei Qin;Chu Wang-.Functional Proteomics Driven by Chemical and Computational Approaches)[J].中国化学（英文版）,2022(05):628-634
A类：
ligandability,dues
B类：
Functional,Proteomics,Driven,by,Chemical,Computational,Approaches,proteomics,is,powerful,approach,globally,investigate,functions,their,significance,Activity,profiling,ABPP,has,been,widely,applied,explore,complex,biological,systems,Herein,summarized,our,efforts,veloping,chemical,probes,pipelines,identify,targets,certain,post,translational,modifications,PTMs,covalent,drugs,natural,products,cellular,metabolites,Furthermore,computer,aided,strategies,were,developed,functional,resi,including,hyper,reactive,cysteines,sites,selenoproteins,proximal,anchors,activation
AB值：
0.705269
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