典型文献
Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy
文献摘要：
The low immunogenicity of tumors remains one of the major limitations of cancer immunotherapy.Herein,we report a bacterial metabo-lism-initiated and photothermal-enhanced nanocatalytic therapy strategy to completely eradicate primary tumor by triggering highly effective antitumor immune responses.Briefly,a microbiotic nanomedicine,designated as Cu2O@ΔSt,has been constructed by conjugating PEGylated Cu2O nanoparticles on the surface of an engineered Salmonella typhimurium strain(ΔSt).Owing to the natural hypoxia tropism of ΔSt,Cu2O@ΔSt could selectively colonize hypoxic solid tumors,thus minimizing the adverse effects of the bacteria on normal tis-sues.Upon bacterial metabolism within the tumor,Cu2O@ΔSt generates H2S gas and other acidic substances in the tumor microenvironment(TME),which will in situ trigger the sulfidation of Cu2O to form CuS facilitating tumor-specific photothermal therapy(PTT)under local NIR laser irradiation on the one hand.Meanwhile,the dissolved Cu+ions from Cu2O into the acidified TME enables the nanocatalytic tumor therapy by catalyzing the Fenton-like reaction of decom-posing endogenous H2O2 into cytotoxic hydroxyl radicals(·OH)on the other hand.Such a bacterial metabolism-triggered PTT-enhanced nanocatalytic treatment could effectively destroy tumor cells and induce a massive release of tumor antigens and damage-associated molecular patterns,thereby sensitizing tumors to checkpoint blockade(ICB)therapy.The combined nanocatalytic and ICB therapy results in the much-inhibited growth of distant and metastatic tumors,and more importantly,induces a powerful immunological memory effect after the primary tumor ablation.
文献关键词：
中图分类号：
作者姓名：
Wencheng Wu;Yinying Pu;Shuang Gao;Yucui Shen;Min Zhou;Heliang Yao;Jianlin Shi
作者机构：
The State Key Lab of High Performance Ceramics and Superfine Microstructures,Shanghai Institute of Ceramics,Chinese Academy of Sciences;Research Unit of Shanghai Nanocatalytic Medicine in Specific Therapy for Serious Disease,Chinese Academy of Medical Sciences(2021RU012),Shanghai 200050,People's Republic of China;Department of Medical Ultrasound,Shanghai Tenth People's Hospital,Ultrasound Research and Education Institute,Tongji University Cancer Center,Tongji University School of Medicine,Shanghai 200072,People's Republic of China
文献出处：
引用格式：
[1]Wencheng Wu;Yinying Pu;Shuang Gao;Yucui Shen;Min Zhou;Heliang Yao;Jianlin Shi-.Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy)[J].纳微快报（英文）,2022(12):549-569
A类：
nanocatalytic,microbiotic,Cu+ions,acidified
B类：
Bacterial,Metabolism,Initiated,Nanocatalytic,Tumor,Immunotherapy,low,immunogenicity,tumors,remains,major,limitations,cancer,immunotherapy,Herein,report,bacterial,initiated,photothermal,enhanced,strategy,completely,eradicate,primary,triggering,highly,antitumor,immune,responses,Briefly,nanomedicine,designated,Cu2O,St,has,been,constructed,conjugating,PEGylated,nanoparticles,surface,engineered,Salmonella,typhimurium,strain,Owing,natural,hypoxia,tropism,could,selectively,colonize,hypoxic,solid,thus,minimizing,adverse,effects,normal,tis,sues,Upon,metabolism,within,generates,H2S,gas,acidic,substances,microenvironment,TME,which,will,situ,sulfidation,form,CuS,facilitating,specific,PTT,under,local,NIR,laser,irradiation,hand,Meanwhile,dissolved,from,into,enables,catalyzing,Fenton,like,reaction,decom,posing,endogenous,H2O2,cytotoxic,hydroxyl,radicals,Such,triggered,treatment,effectively,destroy,cells,massive,release,antigens,damage,associated,molecular,patterns,thereby,sensitizing,checkpoint,blockade,ICB,combined,results,much,inhibited,growth,distant,metastatic,more,importantly,induces,powerful,immunological,memory,after,ablation
AB值：
0.632802
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