典型文献
Amphiphilic Block Copolymer Micelles for Gene Delivery
文献摘要：
Gene therapy is a promising method to treat acquired and inherited diseases by introducing exogenous genes into specific recipient cells.Polymeric micelles with different nanoscopic morphologies and properties hold great promise for gene delivery system.Conventional cationic polymers,poly(ethyleneimine)(PEI),poly(L-lysine)(PLL),poly(2-dimethyla-minoethyl methacrylate)(PDMAEMA)and novel cationic polymers poly(2-oxazoline)s(Poxs),have been incorporated into block copolymers and decorated with targeting moieties to enhance transfection efficiency.In order to minimize cytotoxicity,nonionic block copolymer micelles are utilized to load gene through hydrophilic and hydrophobic interactions or covalent conjugations,recently.From our perspective,properties(shape,size,and mechanical stiffness,etc.)of block copolymer micelles may significantly affect cytotoxicity,transfection efficiency,circulation time,and load capacity of gene vectors in vivo and in vitro.This review briefly sums up recent efforts in cationic and nonionic amphiphilic polymeric micelles for gene delivery.
文献关键词：
中图分类号：
作者姓名：
LI Qin;JIN Bixin;LUO Yunjun;LI Xiaoyu
作者机构：
School of Material Science and Engineering,Beijing Institute of Techno-logy,Beijing 100081,P.R.China;Key Laboratory of High Energy Density Materials,Ministry of Education,Beijing Institute of Technology,Beijing 100081,P.R.China;Experimental Centre of Advanced Materials,Beijing Institute of Techno-logy,Beijing 100081,P.R.China
文献出处：
引用格式：
[1]LI Qin;JIN Bixin;LUO Yunjun;LI Xiaoyu-.Amphiphilic Block Copolymer Micelles for Gene Delivery)[J].高等学校化学研究（英文版）,2022(06):1368-1379
A类：
Amphiphilic,Micelles,ethyleneimine,dimethyla,minoethyl,Poxs,conjugations
B类：
Block,Copolymer,Gene,Delivery,therapy,promising,method,treat,acquired,inherited,diseases,by,introducing,exogenous,genes,into,specific,recipient,cells,Polymeric,micelles,different,nanoscopic,morphologies,properties,hold,great,promise,delivery,system,Conventional,cationic,PEI,lysine,PLL,methacrylate,PDMAEMA,novel,oxazoline,have,been,incorporated,block,copolymers,decorated,targeting,moieties,enhance,transfection,efficiency,In,order,minimize,cytotoxicity,nonionic,are,utilized,load,through,hydrophilic,hydrophobic,interactions,covalent,recently,From,our,perspective,shape,size,mechanical,stiffness,etc,may,significantly,affect,circulation,capacity,vectors,vivo,vitro,This,review,briefly,sums,up,efforts,amphiphilic,polymeric
AB值：
0.61961
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