Dark tea(containing Eurotium cristatum)and black tea have hypoglycemic effects.The black brick tea with fungal growth is obtained from black tea by adding E.cristatum,followed by steaming,pressing,fungal growth,and drying.However,the hypoglycemic effects of black brick tea are still unexplored.Here,we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice model.Both these types of black tea could lower the content of blood glucose and increase the content of hepatic glycogen by upregulating the proteins and mRNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase,glycogen synthase,protein kinase B and phosphoinositide-dependent protein kinase-1 and downregulating the protein and mRNA expression of glycogen synthase kinase 3β.These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low content of malondialdehyde.These teas can promote blood glucose transport and absorption by upregulating the protein and mRNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and mRNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2.Our study suggests that the black brick tea was more effective than the black tea in terms of hypoglycemic.

Wei Xu;Yang Zhou;Ling Lin;Dongyin Yuan;Yingqi Peng;Li Li;Wenjun Xiao;Zhihua Gong

Key Laboratory of Tea Science of Ministry of Education,Hunan Agricultural University,Changsha 410128,China;National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients,Hunan Agricultural University,Changsha 410128,China;Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients,Changsha 410128,China;Hunan Baojiachong Tea Farm Co.Ltd.,Yiyang 413500,China

食品科学与人类健康（英文）

[1]Wei Xu;Yang Zhou;Ling Lin;Dongyin Yuan;Yingqi Peng;Li Li;Wenjun Xiao;Zhihua Gong-.Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model)[J].食品科学与人类健康（英文）,2022(03):711-718

Hypoglycemic,bisphosphate3,biphosphatase

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