Pyrimidine nucleosides(PN)are abundant in mammalian milk and mainly involved in glycogen depo-sition and lipid metabolism.To investigate the effects of maternal supplementation with pyrimidine nucleoside on glucose,fatty acids(FAs),and amino acids(AAs)metabolism in neonatal piglets.Forty pregnant sows were randomly assigned into the control(CON)group(fed a basal diet,n=20)or the PN group(fed a basal diet supplemented with PN at 150 g/t,n=20).Litter size,born alive and birth litter weight were recorded.The serum and placenta of sows,and jejunum and liver of neonatal piglets were sampled.The results indicated that supplementing sow diets with PN decreased birth mortality and increased the birth weight of piglets(P＜0.05).In addition,neonates from sows supplemented with PN had higher glucose levels in serum and liver compared with the CON group(P＜0.05).Moreover,maternal PN supplementation regulated the ratio of saturated FAs and polyunsaturated FAs,and AAs content in serum and liver of piglets(P＜0.05).Furthermore,an up-regulation of mRNA expression of genes related to glucose and AA transport were observed in the neonatal jejunum from the PN group(P＜0.05).Additionally,hepatic protein expressions of phosphorylated hormone-sensitive lipase(P-HSL),HSL,sterol regulatory element-binding transcription factor 1c(SREBP-1c),and phosphorylated protein kinase B(P-AKT)was higher in the piglets from the PN group than the CON group(P＜0.05).Together,maternal PN supplementation may regulate nutrient metabolism of neonatal piglets by modulating the gene expression of glucose and AA transporters in placenta and jejunum,and the gene and protein expression of key enzymes related to lipid metabolism in liver of neonatal piglets,which may improve the reproductive performance of sows.

Lu-min Gao;Gang-yi Liu;Hong-ling Wang;Teketay Wassie;Xin Wu

CAS Key Laboratory of Agro-ecological Processes in Subtropical Region,Institute of Subtropical Agriculture,Chinese Academy of Sciences;Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production,Changsha,410125,China;National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production

动物营养（英文）

[1]Lu-min Gao;Gang-yi Liu;Hong-ling Wang;Teketay Wassie;Xin Wu-.Maternal pyrimidine nucleoside supplementation regulates fatty acid,amino acid and glucose metabolism of neonatal piglets)[J].动物营养（英文）,2022(04):309-321

Pyrimidine

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