典型文献
Flavonoids of Rosa rugosa Thunb.inhibit tumor proliferation and metastasis in human hepatocellular carcinoma HepG2 cells
文献摘要：
Rosa rugosa Thunb.is recognized as both medicine and edible in China.The article investigated the antitumor activity of rose flavonoids.Water-extracted rose flavonoids(RFW)and etthanol-extracted rose flavonoids(RFE)were achieved by extracting with distilled water and 70％ethanol,respectively.The effects of the two extracts on proliferation inhibition,apoptosis inducement and metastasis prevention of human HepG2 hepatocellular carcinoma cell lines were tested,via optical/fluorescence microscopy,MTT detection,Transwell assay,flow cytometry and Western blot,etc.The results indicated that rose flavonoids at low concentration(10-40 μg/mL)had a better inhibitory effect on migration and invasion of HepG2 cells in a dose-dependent manner,while rose flavonoids at high concentration(80-160 μg/mL)could induce apoptosis of HepG2 cells by up-regulating the expression of pro-apoptotic proteins p53 and Bax,and down-regulating the expression of anti-apoptotic proteins Bcl-2,leading to the functioning of caspase-3 and caspase-9.The effect of RFE at the same concentration was significantly better than that of RFW.Conclusion,this study found that rose flavonoids had a certain inhibitory effect on proliferation and metastasis of human liver cancer cells HepG2,indicating the application of rose flavonoids in preventing and treating of liver cancer.
文献关键词：
中图分类号：
作者姓名：
Zhiguo Zhang;Meilin Wang;Shu Xing;Chen Zhang
作者机构：
School of Food Science and Engineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China;School of Chemistry and Pharmaceutical Engineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China;School of Science,The Hong Kong University of Science and Technology,Hong Kong,China
文献出处：
引用格式：
[1]Zhiguo Zhang;Meilin Wang;Shu Xing;Chen Zhang-.Flavonoids of Rosa rugosa Thunb.inhibit tumor proliferation and metastasis in human hepatocellular carcinoma HepG2 cells)[J].食品科学与人类健康（英文）,2022(02):374-382
A类：
RFW,etthanol
B类：
Flavonoids,Rosa,rugosa,Thunb,proliferation,metastasis,human,hepatocellular,carcinoma,HepG2,cells,recognized,both,medicine,edible,China,article,investigated,antitumor,activity,rose,flavonoids,Water,extracted,RFE,were,achieved,by,extracting,distilled,water,ethanol,respectively,effects,two,extracts,inhibition,apoptosis,inducement,prevention,lines,tested,via,optical,fluorescence,microscopy,MTT,detection,Transwell,assay,flow,cytometry,blot,etc,results,indicated,that,concentration,had,better,inhibitory,migration,invasion,dose,dependent,manner,while,high,could,up,regulating,expression,apoptotic,proteins,p53,Bax,down,Bcl,leading,functioning,caspase,same,was,significantly,Conclusion,this,study,found,certain,liver,cancer,indicating,application,preventing,treating
AB值：
0.508868
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