典型文献
6,6'-Bieckol induces apoptosis and suppresses TGF-β-induced epithelial-mesenchymal transition in non-small lung cancer cells
文献摘要：
Objective:In this study,the aim was to investigate the inhibitory effect of 6,6'-bieckol on the migration and epithelial-mesenchymal transition(EMT)of non-small cell lung cancer(NSCLC)cells,and explore its potential molecular mechanisms.Methods:Cell migration was measured using a CCK8,wound healing,and transwell migration assay.Apoptosis was determined using an Annexin V/propidium iodide staining.Western blotting and immunofluorescence were used to examine the expression level of apoptosis-related proteins and EMT marker proteins.Results:The results showed that 6,6'-bieckol inhibited migration and induced apoptosis of NSCLC cells.Furthermore,6,6'-bieckol had significantly up-regulated the E-cadherin and down-regulated Snail1 and Twist1 transcriptional levels.6,6'-Bieckol might inhibit TGF-β-induced EMT by down-regulating Snail1 and Twist1 and up-regulating E-cadherin in lung cancer cells.Conclusion:It is suggested that 6,6'-bieckol has the potential to be developed as a therapeutic candidate for lung cancer.
文献关键词：
中图分类号：
作者姓名：
Yongxin Li;Man Liu;Kunlong Yang;Jun Tian
作者机构：
Department of Biomedicine and Food Science,School of Life Science,Jiangsu Normal University,Xuzhou 221116,China
文献出处：
引用格式：
[1]Yongxin Li;Man Liu;Kunlong Yang;Jun Tian-.6,6'-Bieckol induces apoptosis and suppresses TGF-β-induced epithelial-mesenchymal transition in non-small lung cancer cells)[J].中草药（英文版）,2022(02):254-262
A类：
Bieckol,bieckol
B类：
induces,apoptosis,suppresses,TGF,induced,epithelial,mesenchymal,transition,small,lung,cancer,cells,Objective,In,this,study,aim,was,investigate,inhibitory,effect,migration,EMT,NSCLC,explore,its,potential,molecular,mechanisms,Methods,Cell,measured,using,CCK8,wound,healing,transwell,assay,Apoptosis,determined,Annexin,propidium,iodide,staining,blotting,immunofluorescence,were,used,examine,expression,related,proteins,marker,Results,results,showed,that,inhibited,Furthermore,had,significantly,regulated,cadherin,down,Snail1,Twist1,transcriptional,levels,might,by,regulating,Conclusion,It,suggested,has,be,developed,therapeutic,candidate
AB值：
0.537141
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