典型文献
Essential oil from Saussurea costus inhibits proliferation and migration of Eca109 cells via mitochondrial apoptosis and STAT3 signaling
文献摘要：
Objective: To investigate the effect and its underlying molecular mechanisms of essential oil from Saussurea costus in esophageal cancer cell line Eca109. Methods: The chemical composition of essential oil from Saussurea costus was investigated by gas chromatography-mass spectrometry (GC-MS). The anti-proliferative, anti-migrative, and apoptotic effects of essential oil from Saussurea costus against Eca109 cells were analyzed. Moreover, the expression of proteins associated with cell cycle, metastasis, and apoptosis was determined. Results: GC-MS analysis showed that essential oil from Saussurea costus was predominantly comprised of sesquiterpenes. Saussurea costus essential oil inhibited the viability of Eca109 cells in a dose-and time-dependent manner with IC50 values of (24.29±1.49), (19.16±2.27) and (6.97±0.86) μg/mL at 12, 24, and 48 h, respectively. The expression levels of target proteins in the cell cycle (phase G1/S), including cyclin D1, p21, and p53, were affected by Saussurea costus essential oil. The essential oil also downregulated the expression of metastasis-related proteins MMP-9 and MMP-2. Moreover, it induced apoptosis of Eca109 cells through the mitochondrial pathway, as well as inhibition of STAT3 phosphorylation. Conclusions: The essential oil from Saussurea costus exhibited anti-proliferative, anti-migrative, and apoptotic effects on Eca109 cells, and could be further explored as a potential anti-esophageal cancer agent.
文献关键词：
中图分类号：
作者姓名：
Xia-Fen Hu;Wan-Xin Liu;Ren Zhang;Wei Zhang;Chao Wang;Meng Chen;Rong Shu;Xin-Zhou Yang;Qiang Wang
作者机构：
Institute of Infection,Immunology and Tumor Microenvironment,Hubei Province Key Laboratory of Occupational Hazard Identification and Control,Wuhan Asia General Hospital,Medical College,Wuhan University of Science and Technology,Wuhan,Hubei 430065,China;The Third People's Hospital of Hubei Province,Zhongshan Hospital of Hubei Province,Wuhan,Hubei 430030,China;School of Pharmaceutical Sciences,South-Central University for Nationalities,182 Minzu Road,Wuhan,Hubei 430074,China
文献出处：
引用格式：
[1]Xia-Fen Hu;Wan-Xin Liu;Ren Zhang;Wei Zhang;Chao Wang;Meng Chen;Rong Shu;Xin-Zhou Yang;Qiang Wang-.Essential oil from Saussurea costus inhibits proliferation and migration of Eca109 cells via mitochondrial apoptosis and STAT3 signaling)[J].亚太热带生物医学杂志（英文版）,2022(06):253-261
A类：
costus,migrative
B类：
Essential,oil,from,Saussurea,inhibits,proliferation,migration,Eca109,cells,mitochondrial,apoptosis,STAT3,signaling,Objective,To,underlying,molecular,mechanisms,essential,esophageal,cancer,line,Methods,chemical,composition,was,investigated,by,gas,chromatography,mass,spectrometry,anti,proliferative,apoptotic,effects,against,were,analyzed,Moreover,expression,proteins,associated,cycle,metastasis,determined,Results,analysis,showed,that,predominantly,comprised,sesquiterpenes,inhibited,viability,dose,dependent,manner,IC50,values,respectively,levels,target,phase,G1,including,cyclin,D1,p21,p53,affected,also,downregulated,related,MMP,induced,through,pathway,well,inhibition,phosphorylation,Conclusions,exhibited,could,be,further,explored,potential,agent
AB值：
0.430612
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