典型文献
Sanguinarine suppresses cell proliferation,migration and invasion in nasopharyngeal carcinoma via inhibiting mTOR signaling
文献摘要：
OBJECTIVE:To confirm the anti-NPC effect of sanguinarine(SA)through a series of wet experiments.METHODS:NPC cell viability was determined by proliferation experiment.Cell clone formation experiment,cell scratch test,transwell migration and invasion experiment and flow cytometry-based cell apoptosis assay were further performed.In addition,Western blotting was performed to investigate the cell signaling pathway.All the relevant experimental data were statistically processed using SPSS 16.0 software.RESULTS:The results showed that sanguinarine represented a time and dose dependent inhibition effects on NPC cell proliferation including the low differentiated CNE2 cells and high metastatic 5-8F cells,along with the cell cloning ability reduction.In addition,sanguinarine has a certain inhibitory effect on the invasion and migration of NPC cells.Mechanistically,sanguinarine displayed the anti-NPC effects mainly involved into the suppression of mTOR signaling and cell apoptosis,which is closely associated with the tumor growth and metastatic malignancy.CONCLUSIONS:Collectively,we discover that sanguinarine is a new high-efficiency anti-NPC monomer of Chinese medicine,with a value for the follow-up pre-clinical research.
文献关键词：
中图分类号：
作者姓名：
YANG Mengzhe;ZHANG Beibei;LIANG Zhenqiang;CHENG Nannan;Lü Anqiao;YANG Jianyu;GUO Xingzhe;BAI Xianyu;HUANG Yuanjiao;JIAO Aijun;XU Ning
作者机构：
School of Basic Medical Sciences,Guangxi Medical University,Nanning 530021,China;Institute of Biomedical Research,Yunnan University,Kunming 650500,China;Department of Otolaryngology-Head and Neck Surgery,the Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China;Life Science Institute,Guangxi Medical University,Nanning 530021,China;Pharmaceutical College,Guangxi Medical University,Nanning 530021,China;Department of Neurology,the Fifth Affiliated Hospital of Guangxi Medical University,Nanning 530021,China
文献出处：
引用格式：
[1]YANG Mengzhe;ZHANG Beibei;LIANG Zhenqiang;CHENG Nannan;Lü Anqiao;YANG Jianyu;GUO Xingzhe;BAI Xianyu;HUANG Yuanjiao;JIAO Aijun;XU Ning-.Sanguinarine suppresses cell proliferation,migration and invasion in nasopharyngeal carcinoma via inhibiting mTOR signaling)[J].中医杂志（英文版）,2022(05):687-692
A类：
Sanguinarine,sanguinarine
B类：
suppresses,proliferation,migration,invasion,nasopharyngeal,carcinoma,inhibiting,mTOR,signaling,OBJECTIVE,To,confirm,anti,NPC,SA,through,series,wet,experiments,METHODS,viability,was,determined,by,Cell,clone,formation,scratch,test,transwell,flow,cytometry,apoptosis,assay,were,further,performed,In,addition,blotting,investigate,pathway,All,relevant,experimental,data,statistically,processed,using,software,RESULTS,results,showed,that,represented,dose,dependent,inhibition,effects,including,differentiated,CNE2,cells,high,metastatic,8F,along,cloning,reduction,has,certain,inhibitory,Mechanistically,displayed,mainly,involved,into,suppression,which,closely,associated,tumor,growth,malignancy,CONCLUSIONS,Collectively,discover,new,efficiency,monomer,Chinese,medicine,value,follow,clinical,research
AB值：
0.580369
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