典型文献
Natural product-based radiopharmaceuticals:Focus on curcumin and its analogs,flavonoids,and marine peptides
文献摘要：
Natural products provide a bountiful supply of pharmacologically relevant precursors for the develop-ment of various drug-related molecules,including radiopharmaceuticals.However,current knowledge regarding the importance of natural products in developing new radiopharmaceuticals remains limited.To date,several radionuclides,including gallium-68,technetium-99m,fluorine-18,iodine-131,and iodine-125,have been extensively studied for the synthesis of diagnostic and therapeutic radiophar-maceuticals.The availability of various radiolabeling methods allows the incorporation of these radio-nuclides into bioactive molecules in a practical and efficient manner.Of the radiolabeling methods,direct radioiodination,radiometal complexation,and halogenation are generally suitable for natural products owing to their simplicity and robustness.This review highlights the pharmacological benefits of cur-cumin and its analogs,flavonoids,and marine peptides in treating human pathologies and provides a perspective on the potential use of these bioactive compounds as molecular templates for the design and development of new radiopharmaceuticals.Additionally,this review provides insights into the current strategies for labeling natural products with various radionuclides using either direct or indirect methods.
文献关键词：
中图分类号：
作者姓名：
Hendris Wongso
作者机构：
Labeled Compound and Radiometry Division,Center for Applied Nuclear Science and Technology,National Nuclear Energy Agency,Bandung,40132,Indonesia
文献出处：
引用格式：
[1]Hendris Wongso-.Natural product-based radiopharmaceuticals:Focus on curcumin and its analogs,flavonoids,and marine peptides)[J].药物分析学报（英文）,2022(03):380-393
A类：
bountiful,radiophar,maceuticals,radiolabeling,radioiodination,radiometal,cumin
B类：
Natural,radiopharmaceuticals,Focus,curcumin,analogs,flavonoids,marine,peptides,products,supply,pharmacologically,relevant,precursors,various,drug,related,molecules,including,However,current,knowledge,regarding,importance,natural,developing,new,remains,limited,To,date,several,radionuclides,gallium,technetium,99m,fluorine,iodine,have,been,extensively,studied,synthesis,diagnostic,therapeutic,availability,methods,allows,incorporation,these,into,bioactive,practical,efficient,manner,Of,complexation,halogenation,are,generally,suitable,owing,their,simplicity,robustness,This,review,highlights,benefits,treating,human,pathologies,provides,perspective,potential,use,compounds,molecular,templates,design,development,Additionally,this,insights,strategies,using,either,indirect
AB值：
0.530118
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