Natural products,and especially the active ingredients found in traditional Chinese medicine(TCM),have a thousand-year-long history of clinical use and a strong theoretical basis in TCM.As such,traditional remedies provide shortcuts for the development of original new drugs in China,and increasing numbers of natural products are showing great therapeutic potential in various diseases.This paper re-views the molecular mechanisms of action of natural products from different sources used in the treat-ment of inflammatory diseases and cancer,introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients,enumerates the expansive list of TCM used to treat inflammatory diseases and cancer,and summarizes the patterns of action of emerging technologies such as single-cell multiomics,network pharmacology,and artificial intelligence in the phar-macological studies of natural products to provide insights for the development of innovative natural product-based drugs.Our hope is that we can make use of advances in target identification and single-cell multiomics to obtain a deeper understanding of actions of mechanisms of natural products that will allow innovation and revitalization of TCM and its swift industrialization and internationalization.

Yuyu Zhu;Zijun Ouyang;Haojie Du;Meijing Wang;Jiaojiao Wang;Haiyan Sun;Lingdong Kong;Qiang Xu;Hongyue Ma;Yang Sun

College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;Institute of Marine Biomedicine,School of Food and Drug,Shenzhen Polytechnic,Shenzhen 518055,China;State Key Laboratory of Pharmaceutical Biotechnology,School of Life Science,Nanjing University,Nanjing 210023,China;Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou Medical University,Xuzhou 221004,China

药学学报（英文版）

[1]Yuyu Zhu;Zijun Ouyang;Haojie Du;Meijing Wang;Jiaojiao Wang;Haiyan Sun;Lingdong Kong;Qiang Xu;Hongyue Ma;Yang Sun-.New opportunities and challenges of natural products research:When target identification meets single-cell multiomics)[J].药学学报（英文版）,2022(11):4011-4039

multiomics,shortcuts,enumerates,macological

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