典型文献
Potential application of proteolysis targeting chimera(PROTAC)modification technology in natural products for their targeted protein degradation
文献摘要：
There are numerous evaluations of natural products,of which majority are food bioactives,performed up to date for their various health beneficial activities via targeting specific proteins.However,the direct identification of a targeted protein remains unexplored for natural occurring compounds.Proteolysis targeting chimera(PROTAC)is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway.As the agents in protein degradation dependent on ubiquitin ligase,the bifunctional molecule connects the target protein ligand and E3 ligase ligand together via an appropriate linker.It is highly selective and efficient to induce the ubiquitin-mediated degradation of targeted binding proteins.Therefore,it has been demonstrated that the PROTAC technology has broad application in the modulation of the target protein level.In this review,we outlined the advances in PROTAC combined molecule compounds,summarized its quantitative structure-activity relationship,and finally reviewed the methods applied in identifying the target proteins of natural products.We hope it will provide an insightful application of PROTAC techniques in the target protein identification of natural products including food bioactive molecules.
文献关键词：
中图分类号：
作者姓名：
Guliang Yang;Haiyan Zhong;Xinxin Xia;Zhiwen Qi;Chengzhang Wang;Shiming Li
作者机构：
National Engineering Laboratory for Rice and By-products Processing,Food Science and Engineering College,Central South University of Forestry and Technology,Changsha 410004,China;Institute of Chemical Industry of Forest Products,CAF,Nanjing 210042,China;Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization,Huanggang Normal University,Huanggang 438000,China
文献出处：
引用格式：
[1]Guliang Yang;Haiyan Zhong;Xinxin Xia;Zhiwen Qi;Chengzhang Wang;Shiming Li-.Potential application of proteolysis targeting chimera(PROTAC)modification technology in natural products for their targeted protein degradation)[J].食品科学与人类健康（英文）,2022(02):199-207
A类：
bioactives,Proteolysis
B类：
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AB值：
0.519814
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