典型文献
Associations of early-life factors and indoor environmental exposure with asthma among children:a case-control study in Chongqing,China
文献摘要：
Background Childhood asthma has substantial effects on children's health.It is important to identify influencing factors in early life in the development of childhood asthma.We aim to evaluate the effects of early-life factors and indoor environ-mental exposure on childhood asthma in Chongqing,China.Method We designed a case-control study to enrol children with asthma aged 3 to＜14 years old and controls in Chongqing,China.The"Children's Early Life and Indoor Environment Survey"was used to collect the early-life factors and indoor environmental exposure of foetuses in utero and of infants during the first 3 years of life.A multivariate logistic regression model was used to evaluate the association between independent variables and childhood asthma and the interaction of early-life factors and environmental exposure.Results A total of 160 asthma cases and 247 controls were included in this study.The mean ages of the cases and controls were 5.53±1.88 and 5.72±2.34 years,respectively(P=0.192).Early-life factors and indoor environmental exposure were independently associated with childhood asthma.Infectious diseases of the respiratory system in children under 3 years old[adjusted odds ratio(OR)=5.76,95％confidence interval(CI)2.49-13.30],bedroom air conditioner use(adjusted OR=4.61,95％CI 1.45-14.64),and bedroom dampness/mould(adjusted OR=2.98,95％CI 1.54-5.75)ranked as the three most significant exposures associated with the risk of childhood asthma.Other factors associated with an increased risk of childhood asthma included second-hand smoke exposure in early life(adjusted OR=1.93,95％CI 1.24-3.00),neonatal pneumonia(adjusted OR=1.90,95％CI 1.05-3.42)and maternal allergic diseases during pregnancy(adjusted OR=2.13,95％CI 1.10-4.10).The interaction effects of child second-hand smoke exposure with other covariates were not found to be statistically significant.Conclusions Early-life factors and indoor environmental exposure are closely related to childhood asthma in Chongqing,China.Further interventions and management in the early life of children should be considered to prevent and control child-hood asthma in Chongqing and similar cities.
文献关键词：
中图分类号：
作者姓名：
Yun-Tian Deng;Xue-Mei Li;En-Mei Liu;Wen-Kui Xiong;Shuo Wang;Rui Zhu;Yu-Bin Ding;Zhao-Hui Zhong
作者机构：
The First Clinical College,Chongqing Medical University,Chongqing,China;Pediatric Outpatient,Chongqing Health Center for Women and Children,Chongqing,China;National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing,China;Department of Respiratory Medicine,Children's Hospital of Chongqing Medical University,Chongqing,China;School of Public Health and Management,Chongqing Medical University,Chongqing,China;School of Public Health and Management,Research Center for Medicine and Social Development,Innovation Center for Social Risk Governance in Health,Chongqing Medical University,No.1,Medical School Road,Yu zhong District,Chongqing,China
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引用格式：
[1]Yun-Tian Deng;Xue-Mei Li;En-Mei Liu;Wen-Kui Xiong;Shuo Wang;Rui Zhu;Yu-Bin Ding;Zhao-Hui Zhong-.Associations of early-life factors and indoor environmental exposure with asthma among children:a case-control study in Chongqing,China)[J].世界儿科杂志（英文版）,2022(03):186-195
A类：
enrol,foetuses
B类：
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AB值：
0.417238
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