典型文献
Risk factors associated with the progression from mild keloids to severe keloids
文献摘要：
Background::Keloids are benign fibrous growths that are caused by excessive tissue build-up. Severe keloids exert more significant effects on patients’ quality of life than do mild keloids. We aimed to identify factors associated with the progression from mild keloids to severe keloids, as distinct from those associated with the formation of keloids.Methods::In this retrospective case-control study, 251 patients diagnosed with keloids at West China Hospital between November 2018 and April 2021 were grouped according to the severity of lesions (mild [
n = 162] or severe [
n = 89]). We collected their basic characteristics, living habits, incomes, comorbidities, and keloid characteristics from Electronic Medical Records in the hospital and the patients’ interviews. Conditional multivariable regression was performed to identify the independent risk factors for the progression of keloids.
Results::Eighty-nine patients (35.5%) were classified as having severe keloids. We found the distribution of severe keloids varied with sex, age, excessive scrubbing of keloids, family income, the comorbidity of rheumatism, disease duration, characteristics of the location, location in sites of high-stretch tension, the severity and frequency of pain, the severity of pruritus, and infection. Multivariable analysis revealed significant associations between severe keloids and infection (odds ratio [OR], 3.55;
P = 0.005), excessive scrubbing of keloids (OR, 8.65;
P = 0.001), low or middle family income (OR, 13.44;
P = 0.021), comorbidity of rheumatism (OR, 18.97;
P = 0.021), multiple keloids located at multiple sites (OR, 3.18;
P = 0.033), and disease duration >15 years (OR, 2.98;
P = 0.046).
Conclusion::Doctors should implement more active and thorough measures to minimize the progression of mild keloids in patients who have any of the following risk factors: infection, excessive scrubbing of keloids, low or middle family income, comorbidity of rheumatism, multiple keloids located at multiple sites, and disease duration >15 years.
文献关键词：
Keloid;Disease progression;Risk factors;Multivariate analysis
中图分类号：
作者姓名：
Liu Ruolin;Xiao Haitao;Wang Ru;Li Wei;Deng Ke;Cen Ying;Xu Xuewen
作者机构：
Department of Burn and Plastic Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China;Laboratory of Mitochondrial and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
文献出处：
引用格式：
[1]Liu Ruolin;Xiao Haitao;Wang Ru;Li Wei;Deng Ke;Cen Ying;Xu Xuewen-.Risk factors associated with the progression from mild keloids to severe keloids)[J].中华医学杂志（英文版）,2022(07):828-836
A类：
Keloid
B类：
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AB值：
0.476484
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