Objective: Epidemiological studies indicate that alcohol increases gastric cancer (GC) risk, yet most studies have focused on heavy alcohol intake, leaving other factors understudied. A comprehensive investigation of the effects of the frequency and amount of alcohol intake may help elucidate the GC risk associated with drinking behavior. Methods: The Health Examinees-Gem (HEXA-G) study, a community-based large-scale prospective cohort study, enrolled Korean adults 40–69 years of age between the years 2004 and 2013. Incident GC cases were identified through linkage to Korea Central Cancer Registry data until December 31, 2017. Self-reported questionnaires were used to survey alcohol consumption-related factors (duration, frequency, amount, and type of alcoholic beverages). The frequency and amount of alcohol consumption were combined to explore GC risk according to 4 drinking patterns:"infrequent-light", "frequent-light", "infrequent-heavy", and "frequent-heavy". We used Cox proportional hazard models to estimate the adjusted hazard ratios (HRs) and 95％ confidence intervals (CIs), and investigate the relationship between alcohol intake and GC incidence. Results: A total of 128,218 participants were included in the analysis. During an average follow-up period of 8.6 years, 462 men and 385 women were diagnosed with GC. In men, current drinkers showed a 31％ greater risk of GC than non-drinkers (HR 1.31, 95％ CI 1.03–1.66), whereas no significant association was observed in women. In men, GC risk was associated with a higher frequency (P trend 0.02) and dose of ethanol intake in grams (P trend 0.03). In men, the "frequent-light" (≥5 times/week and <40 g ethanol/day) drinking pattern was associated with a 46％ greater risk of GC (HR 1.46, 95％ CI 1.02–2.07) than the "infrequent-light" pattern (<5 times/week and <40 g ethanol/day). Conclusions: This study suggests that frequent intake of alcohol, even in low quantities per session, increases GC risk. Further research is warranted to evaluate the relationship between alcohol and GC in detail.

Hwi-Won Lee;Dan Huang;Woo-Kyoung Shin;Katherine de la Torre;Minkyo Song;Aesun Shin;Jong-Koo Lee;Daehee Kang

Department of Biomedical Sciences,Seoul National University Graduate School,Seoul 03080,Korea;Department of Preventive Medicine,Seoul National University College of Medicine,Seoul 03080,Korea;Integrated Major in Innovative Medical Science,Seoul National University Graduate School,Seoul 03080,Korea;Department of Family Medicine,Seoul National University Hospital,Seoul 03080,Korea

癌症生物学与医学（英文版）

[1]Hwi-Won Lee;Dan Huang;Woo-Kyoung Shin;Katherine de la Torre;Minkyo Song;Aesun Shin;Jong-Koo Lee;Daehee Kang-.Frequent low dose alcohol intake increases gastric cancer risk: the Health Examinees-Gem (HEXA-G) study)[J].癌症生物学与医学（英文版）,2022(08):1224-1234

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