典型文献
Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?
文献摘要：
Background::Excessive exposure to fluoride can reduce intelligence. Methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 (
MTHFD1) polymorphisms have important roles in neurodevelopment. However, the association of
MTHFD1 polymorphisms with children’s intelligence changes in endemic fluorosis areas has been rarely explored.
Methods::A cross-sectional study was conducted in four randomly selected primary schools in Tongxu County, Henan Province, from April to May in 2017. A total of 694 children aged 8 to 12 years were included in the study with the recruitment by the cluster sampling method. Urinary fluoride (UF) and urinary creatinine were separately determined using the fluoride ion-selective electrode and creatinine assay kit. Children were classified as the high fluoride group and control group according to the median of urinary creatinine-adjusted urinary fluoride (UF
Cr) level. Four loci of
MTHFD1 were genotyped, and the Combined Raven’s Test was used to evaluate children’s intelligence quotient (IQ). Generalized linear model and multinomial logistic regression model were performed to analyze the associations between children’s UF
Cr level,
MTHFD1 polymorphisms, and intelligence. The general linear model was used to explore the effects of gene-environment and gene-gene interaction on intelligence.
Results::In the high fluoride group, children’s IQ scores decreased by 2.502 when the UF
Cr level increased by 1.0 mg/L (β= –2.502, 95% confidence interval [CI]: –4.411, –0.593), and the possibility for having "excellent" intelligence decreased by 46.3% (odds ratio = 0.537, 95% CI: 0.290, 0.994). Children with the GG genotype showed increased IQ scores than those with the AA genotype of rs11627387 locus in the high fluoride group (
P < 0.05). Interactions between fluoride exposure and
MTHFD1 polymorphisms on intelligence were observed (Pinteraction < 0.05).
Conclusion::Our findings suggest that excessive fluoride exposure may have adverse effects on children’s intelligence, and changes in children’s intelligence may be associated with the interaction between fluoride and
MTHFD1 polymorphisms.
文献关键词：
Fluoride;Intelligence;Interaction;MTHFD1 gene
中图分类号：
作者姓名：
Feng Zichen;An Ning;Yu Fangfang;Ma Jun;Li Na;Du Yuhui;Guo Meng;Xu Kaihong;Hou Xiangbo;Li Zhiyuan;Zhou Guoyu;Ba Yue
作者机构：
Department of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China;Department of Endemic Disease, Kaifeng Center for Disease Control and Prevention, Kaifeng, Henan 475004, China;Dietary Center, Zhengzhou Health Vocational College, Zhengzhou, Henan 450122, China
文献出处：
引用格式：
[1]Feng Zichen;An Ning;Yu Fangfang;Ma Jun;Li Na;Du Yuhui;Guo Meng;Xu Kaihong;Hou Xiangbo;Li Zhiyuan;Zhou Guoyu;Ba Yue-.Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?)[J].中华医学杂志（英文版）,2022(15):1846-1854
A类：
cyclohydrolase,formyltetrahydrofolate,Tongxu,UF
,rs11627387,gene
B类：
Do,methylenetetrahydrofolate,dehydrogenase,synthetase,polymorphisms,modify,changes,intelligence,children,areas,endemic,fluorosis,Background,Excessive,exposure,fluoride,can,reduce,Methylenetetrahydrofolate,MTHFD1,have,important,roles,neurodevelopment,However,has,been,rarely,explored,Methods,cross,sectional,study,was,conducted,four,randomly,selected,primary,schools,County,Henan,Province,from,April,May,total,aged,years,were,included,recruitment,by,cluster,sampling,method,Urinary,urinary,creatinine,separately,determined,using,selective,electrode,assay,kit,Children,classified,high,group,control,according,median,adjusted,level,Four,loci,genotyped,Combined,Raven,Test,used,evaluate,quotient,IQ,Generalized,linear,model,multinomial,logistic,regression,performed,analyze,associations,between,general,effects,environment,Results,scores,decreased,when,increased,confidence,interval,possibility,having,excellent,odds,ratio,GG,showed,than,those,AA,locus,Interactions,observed,Pinteraction,Conclusion,Our,findings,suggest,that,excessive,may,adverse,associated,Fluoride,Intelligence
AB值：
0.462915
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