典型文献
Association of low cadmium and mercury exposure with chronic kidney disease among Chinese adults aged ≥80 years: A cross-sectional study
文献摘要：
Background::The heavy metals cadmium (Cd) and mercury (Hg) are known to be widespread environmental contaminants and high occupational exposure adversely affects the risk of chronic kidney disease (CKD). However, evidence from epidemiological studies linking low Cd and Hg exposure (or non-industrial) to the risk of progression to CKD are conflicting. This study aimed to explore the association of low Cd and Hg exposure with the risk of CKD in Chinese adults aged ≥80 years.Methods::The participants were recruited for the Healthy Aging and Biomarkers Cohort Study in 2017, an ongoing perspective survey conducted in longevity areas in China initially involving 3016 older adults. We used logistic regression models to estimate odds ratios (ORs) with 95% confidence intervals of CKD setting Cd and Hg as categorical variables. Logistic regression with restricted cubic spline was used to characterize a dose-response relationships between Cd or Hg concentrations and the risk of CKD in the study population.Results::The ORs for the risk of CKD comparing the fourth to the first quartile of blood Cd, blood Hg, urine Cd, and urine Hg were 1.77, 1.57, 2.03, and 1.50, respectively. Restricted cubic spline models showed that blood Cd and urine Hg were significantly linearly correlated with the risk of CKD, while blood Hg and urine Cd were non-linearly correlated with the risk of CKD with a steeper slope at concentrations <2.30 μg/L and 3.30 μg/g creatinine.Conclusions::Our findings suggest that even low Cd and Hg exposure (or non-industrial) were associated with increased risk of CKD in Chinese oldest old, although we did not find a significant multiplicative and additive interaction between Cd and Hg levels in relation to the risk of CKD.
文献关键词：
Aged, 80 and over;Cadmium;Chronic kidney disease;Mercury
中图分类号：
作者姓名：
Wei Yuan;Lyu Yuebin;Cao Zhaojin;Zhao Feng;Liu Yingchun;Chen Chen;Li Chengcheng;Gu Heng;Lu Feng;Zhou Jinhui;Wu Bing;Liu Yang;Li Juan;Shi Xiaoming
作者机构：
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China;Department of Hygienic Inspection, School of Public Health, Jilin University, Changchun, Jilin 130021, China;Beijing Municipal Health Commission Information Center, Beijing Municipal Health Commission Policy Research Center, Beijing 100034, China;Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin 130021, China
文献出处：
引用格式：
[1]Wei Yuan;Lyu Yuebin;Cao Zhaojin;Zhao Feng;Liu Yingchun;Chen Chen;Li Chengcheng;Gu Heng;Lu Feng;Zhou Jinhui;Wu Bing;Liu Yang;Li Juan;Shi Xiaoming-.Association of low cadmium and mercury exposure with chronic kidney disease among Chinese adults aged ≥80 years: A cross-sectional study)[J].中华医学杂志（英文版）,2022(24):2976-2983
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B类：
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AB值：
0.535066
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