Osteoporosis is a systemic bone disease that affects more than 200 million people worldwide and is caused by the disruption of the equilibrium between osteoclastic bone resorption and osteoblastic bone formation.Sphingosine-1-phosphate(S1P)is a natural,bioactive sphingolipid that has been shown to play a major role in cardiovascular and immunological pathologies by regulating biological and cellular processes,including migration,differentiation,proliferation and survival.Recent studies also suggest a central role for S1 P in bone diseases,including osteoporosis;however,the effects of S1 P,particularly in bone metabolism,remain to be further elucidated.In this review,we summarize the available literature on the role of S1P in bone metabolism with a focus on osteoporosis.On the cellular level,S1P acts as an osteoclast-osteoblast coupling factor to promote osteoblast proliferation and bone formation.Moreover,the recruitment of osteoclast precursors to resorption sites is regulated by the interplay of S1P gradients and S1P receptor expression.From a clinical perspective,increasing evidence suggests that systemically elevated S1P blood levels may serve as an independent risk factor for osteoporosis-related fractures.Taken together,S1P signaling is a potential therapeutic target and may serve as a novel biomarker in patients with systemic bone disease.

Justus M.Grewe;Paul-Richard Knapstein;Antonia Donat;Shan Jiang;Daniel J.Smit;Weixin Xie;Johannes Keller

Department of Trauma and Orthopedic Surgery,University Medical Center Hamburg-Eppendorf,20246 Hamburg,Germany;Clinic and Polyclinic for Vascular Medicine,University Heart Center Hamburg-Eppendorf,20246 Hamburg,Germany;Institute of Biochemistry and Signal Transduction,University Medical Center Hamburg-Eppendorf,20246 Hamburg,Germany

骨研究（英文版）

[1]Justus M.Grewe;Paul-Richard Knapstein;Antonia Donat;Shan Jiang;Daniel J.Smit;Weixin Xie;Johannes Keller-.The role of sphingosine-1-phosphate in bone remodeling and osteoporosis)[J].骨研究（英文版）,2022(02):265-273

osteoclastic

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