典型文献
Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings
文献摘要：
Background: Epidemiological data indicate an association between cadmium exposure and risk of bone fracture; however, clinical treatment of cadmium-induced fracture is limited. Although vitamin C (VC) reportedly reduces cadmium-induced fracture, its pharmacological mechanism remains unexplored. Methods: Thus, we used a network pharmacology approach and molecular docking analysis to identify core targets, functional processes, and biological pathways involved in the anti-fracture action of VC. Results: Bioinformatics identified 17 intersection targets of VC and cadmium-induced fracture. Nine core targets were characterized, including tumor protein p53, epidermal growth factor receptor, proto-oncogene c, mitogen-activated protein kinase-1 (MAPK1), MAPK3, signal transducer and activator of transcription-3, MAPK14, prostaglandin-endoperoxide synthase 2, and estrogen receptor alpha. Interestingly, findings of molecular docking analysis indicated that VC exerted effective binding capacity in cadmium-induced fracture. Furthermore, biological processes, cell components, molecular functions, and pharmacological pathways involved in the action of VC against cadmium-induced fracture were identified and visualized. Conclusions: Based on these findings, we conclude that VC exhibits its anti-cadmium-induced fracture effects by promoting osteoblastic regeneration and proliferation, and inhibiting inflammatory stress. The core targets may serve as biomarkers for diagnosing cadmium-induced fractures.
文献关键词：
中图分类号：
作者姓名：
Rong Li;Songzuo Yu;Xiao Liang;Yu Li;Keng Po Lai
作者机构：
Laboratory of Environmental Pollution and Integrative Omics,Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation,Guilin Medical University,Guilin 541004,China;Department of Neurosurgery,Guigang City People's Hospital,The Eighth Affiliated Hospital of Guangxi Medical University,Guigang 537100,China
文献出处：
引用格式：
[1]Rong Li;Songzuo Yu;Xiao Liang;Yu Li;Keng Po Lai-.Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings)[J].食品科学与人类健康（英文）,2022(05):1384-1391
A类：
biostructural
B类：
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AB值：
0.596885
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