典型文献
Polymorphisms of the Vitamin D Receptor Gene and Sex- Differential Associations with Lipid Profiles in Chinese Han Adults
文献摘要：
Objective To explore the association of single nucleotide polymorphisms (SNPs) of the vitamin D receptor gene (VDR) with circulating lipids considering gender differences. Methods Of the Han Chinese adults recruited from a health examination center for inclusion in the study, the circulating lipids, 25-hydroxyvitamin D (25OHD), and other parameters were measured. The VDR SNPs of Cdx2 (rs11568820), Fok1 (rs2228570), Apa1 (rs7975232), and Taq1 (rs731236) were genotyped with a qPCR test using blood DNA samples, and their associations with lipids were analyzed using logistic regression. Results In the female participants (n = 236 with dyslipidemia and 888 without dyslipidemia), multiple genotype models of Fok1 indicated a positive correlation of B (not A) alleles with LDLC level (P < 0.05). In the male participants (n = 299 with dyslipidemia and 564 without dyslipidemia), the recessive model of Cdx2 and the additive and recessive models of Fok1 differed (P < 0.05) between the HDLC-classified subgroups, respectively, and Fok1 BB and Cdx2 TT presented interactions with 25OHD in the negative associations with HDLC (P < 0.05). Conclusion In the Chinese Han adults included in the study, the Fok1 B-allele of VDR was associated with higher LDLC in females, and the Fok1 B-allele and the Cdx2 T-allele of VDR were associated with lower HDLC in males. The interaction of VD and Fok1 BB or Cdx2 TT in males synergistically decreased HDLC levels.
文献关键词：
中图分类号：
作者姓名：
CHEN Yan Mei;XU Ping;WANG Zhou Tian;ZHU Yu Mei;GONG Chun Mei;HUANG Chang Hua;LIU Xiao Li;ZHOU Ji Chang
作者机构：
School of Public Health(Shenzhen),Sun Yat-sen University,Shenzhen 518100,Guangdong,China;Shenzhen Center for Chronic Disease Control,Shenzhen 518020,Guangdong,China;Shenzhen Qilinshan Sanatorium,Shenzhen 518055,Guangdong,China;Guangdong Province Engineering Laboratory for Nutrition Translation,Guangzhou 510080,Guangdong,China
文献出处：
引用格式：
[1]CHEN Yan Mei;XU Ping;WANG Zhou Tian;ZHU Yu Mei;GONG Chun Mei;HUANG Chang Hua;LIU Xiao Li;ZHOU Ji Chang-.Polymorphisms of the Vitamin D Receptor Gene and Sex- Differential Associations with Lipid Profiles in Chinese Han Adults)[J].生物医学与环境科学（英文版）,2022(02):115-125,中插2-中插10
A类：
rs11568820,Fok1,Apa1,rs7975232,Taq1,rs731236
B类：
Polymorphisms,Vitamin,Receptor,Gene,Sex,Differential,Associations,Lipid,Profiles,Chinese,Han,Adults,Objective,To,explore,single,nucleotide,polymorphisms,SNPs,receptor,gene,VDR,circulating,lipids,considering,gender,differences,Methods,Of,adults,recruited,from,health,examination,center,inclusion,study,hydroxyvitamin,25OHD,other,parameters,were,measured,Cdx2,rs2228570,genotyped,qPCR,test,using,blood,samples,their,associations,analyzed,logistic,regression,Results,In,participants,dyslipidemia,without,multiple,models,indicated,positive,correlation,alleles,LDLC,recessive,additive,differed,between,HDLC,classified,subgroups,respectively,BB,TT,presented,interactions,negative,Conclusion,included,was,associated,higher,females,lower,synergistically,decreased,levels
AB值：
0.452252
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