Background::Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis (ICAS). The platelet-to-lymphocyte ratio (PLR) has recently emerged as a potential inflammatory biomarker. This study aimed to explore the association of the PLR with ICAS in a Chinese Han population.Methods::A total of 2134 participants (518 with ICAS, 1616 without ICAS) were enrolled in this study. ICAS was defined as atherosclerotic stenosis >50% or the occlusion of several main intracranial arteries. Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS. Additional subgroup analyses were performed according to age (<60 vs. ≥ 60 years) and acute ischemic stroke. Results::Multivariate regression analysis showed that a high PLR was associated with a higher risk of ICAS in all participants ( P < 0.001). Compared with the lowest quartile, the fourth PLR quartile was significantly associated with ICAS (OR 1.705, 95% confidence interval 1.278–2.275, P < 0.001). In the subgroups stratified by age, an association between the PLR and ICAS was found in the late-life group ( P < 0.001), but not in the mid-life group ( P = 0.650). In the subgroups stratified by acute ischemic stroke, the relationship between an elevated PLR and a higher risk of ICAS remained unchanged (stroke group, P < 0.001; non-stroke group, P = 0.027). Conclusions::An elevated PLR was associated with a higher risk of ICAS in a Chinese Han population. The PLR might serve as a potential biomarker for ICAS in the elderly population.

Platelet-to-lymphocyte ratio;Intracranial atherosclerotic stenosis;Atherosclerosis;Inflammation

Huang Yanhua;Wang Zuoteng;Zhao Bing;Ma Yahui;Ou Yanan;Hu Hao;Hou Xiaohe;Yu Jintai;Tan Lan

Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong 266071, China;Department of Neurology, Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China

中华医学杂志（英文版）

[1]Huang Yanhua;Wang Zuoteng;Zhao Bing;Ma Yahui;Ou Yanan;Hu Hao;Hou Xiaohe;Yu Jintai;Tan Lan-.An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis)[J].中华医学杂志（英文版）,2022(12):1425-1431

An,elevated,platelet,lymphocyte,ratio,associated,higher,risk,intracranial,atherosclerotic,stenosis,Background,Previous,studies,have,shown,that,inflammation,plays,important,role,ICAS,PLR,has,recently,emerged,potential,inflammatory,biomarker,This,study,aimed,explore,association,Chinese,Han,population,Methods,total,participants,without,were,enrolled,this,was,defined,occlusion,several,arteries,Multivariable,logistic,regression,analyses,used,assess,Additional,performed,according,age,years,acute,ischemic,stroke,Results,Multivariate,analysis,showed,all,Compared,lowest,quartile,fourth,significantly,confidence,interval,subgroups,stratified,by,between,found,life,but,not,mid,relationship,remained,unchanged,Conclusions,might,serve,elderly,Platelet,Intracranial,Atherosclerosis,Inflammation

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