典型文献
Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank
文献摘要：
Background::The risk for chronic kidney disease (CKD) is influenced by genetic predisposition, sex, and lifestyle. Previous research indicates that coffee is a potentially protective factor in CKD. The current study aims to investigate whether sex disparity exists in the coffee–CKD association, and whether genetic risk of CKD or genetic polymorphisms of caffeine metabolism affect this association.Methods::A total of 359,906 participants from the UK Biobank who were enrolled between 2006 and 2010 were included in this prospective cohort study, which aimed to estimate the hazard ratios for coffee intake and incident CKD using a Cox proportional hazard model. Allele scores of CKD and caffeine metabolism were additionally adjusted for in a subsample with qualified genetic data (
n = 255,343). Analyses stratified by genetic predisposition, comorbidities, and sex hormones were performed. Tests based on Bayesian model averaging were conducted to ascertain the robustness of the results.
Results::Coffee was inversely associated with CKD in a dose-dependent manner. The effects of coffee did not differ across different strata of genetic risk for CKD, but were more evident among slower genetically predicted caffeine metabolizers. Significant sex disparity was observed (
P value for interaction = 0.013), in that coffee drinking was only associated with the risk reduction of CKD in females. Subgroup analysis revealed that testosterone and sex hormone-binding globulin (SHBG), but not estradiol, modified the coffee–CKD association.
Conclusions::In addition to the overall inverse coffee–CKD association that was observed in the general population, we could also establish that a sex disparity existed, in that females were more likely to experience the benefit of the association. Testosterone and SHBG may partly account for the sex disparity.
文献关键词：
Coffee;Chronic kidney diseases;Genotype;Sex
中图分类号：
作者姓名：
Tang Lei;Yang Lina;Chen Wenwen;Li Chunyang;Zeng Yu;Yang Huazhen;Hu Yao;Qu Yuanyuan;Song Huan;Zeng Xiaoxi;Fu Ping
作者机构：
Division of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China;Biomedical Big Data Center of West China Hospital, Med-X Center for Informatics, Sichuan University, Chengdu, Sichuan 610041, China;Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland
文献出处：
引用格式：
[1]Tang Lei;Yang Lina;Chen Wenwen;Li Chunyang;Zeng Yu;Yang Huazhen;Hu Yao;Qu Yuanyuan;Song Huan;Zeng Xiaoxi;Fu Ping-.Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank)[J].中华医学杂志（英文版）,2022(12):1414-1424
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B类：
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AB值：
0.535641
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