Background:It remains unclear about the association of muscle mass, strength, and quality with death in the general Chinese population of diverse economical and geographical backgrounds. The present study aimed to comprehensively examine such associations across different regions in China.Methods:Based on the China Kadoorie Biobank study, the present study included 23,290 participants who were aged 38 to 88 years and had no prevalent cardiovascular diseases or cancer. Muscle mass and grip strength were measured using calibrated instruments. Arm muscle quality was defined as the ratio of grip strength to arm muscle mass. Low muscle mass, grip strength, and arm muscle quality were defined as the sex-specific lowest quintiles of muscle mass index, grip strength, and arm muscle quality, respectively. Cox proportional hazards models yielded hazard ratios (HRs) and 95% confidence intervals (CIs) for risks of all-cause mortality in relation to muscle mass, strength, and quality.Results:During a median follow-up of 3.98 years, 739 participants died. The HR (95% CI) of all-cause mortality risk was 1.28 (1.08-1.51) for low appendicular muscle mass index, 1.38 (1.16-1.62) for low total muscle mass index, 1.68 (1.41-2.00) for low grip strength, and 1.41 (1.20-1.66) for low arm muscle quality in models adjusted for sociodemographic characteristics, lifestyle factors, and medical histories.Conclusion:Low muscle mass, grip strength, and arm muscle quality are all associated with short-term increased risks of mortality, indicating the importance of maintaining normal muscle mass, strength, and quality for general Chinese adults.

Muscle;All-cause mortality;Chinese;Prospective;Muscle mass;Muscle strength;Muscle quality

Wu Man;Wei Yuxia;Lv Jun;Guo Yu;Pei Pei;Li Jiachen;Du Huaidong;Yang Ling;Chen Yiping;Sun Xiaohui;Zhang Hua;Chen Junshi;Chen Zhengming;Yu Canqing;Li Liming;on behalf of the China Kadoorie Biobank Collaborative Group

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing 100191, China;Peking University Center for Public Health and Epidemic Preparedness & Responses, Beijing 100191, China;National Coordinating Center of China Kadoorie Biobank, Chinese Academy of Medical Sciences, Beijing 102308, China;Medical Research Council Population Health Research Unit, the University of Oxford, Oxford OX3 7LF, UK;Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK;NCDs Prevention and Control Department, Qingdao CDC, Qingdao, Shandong 266033, China;NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, China

中华医学杂志（英文版）

[1]Wu Man;Wei Yuxia;Lv Jun;Guo Yu;Pei Pei;Li Jiachen;Du Huaidong;Yang Ling;Chen Yiping;Sun Xiaohui;Zhang Hua;Chen Junshi;Chen Zhengming;Yu Canqing;Li Liming;on behalf of the China Kadoorie Biobank Collaborative Group-.Associations of muscle mass, strength, and quality with all-cause mortality in China: a population-based cohort study)[J].中华医学杂志（英文版）,2022(11):1358-1368

Kadoorie

Associations,muscle,mass,strength,quality,all,cause,mortality,China,population,cohort,study,Background,It,remains,unclear,about,death,general,Chinese,diverse,economical,geographical,backgrounds,present,aimed,comprehensively,examine,such,associations,across,different,regions,Methods,Based,Biobank,included,participants,who,were,aged,years,had,prevalent,cardiovascular,diseases,cancer,Muscle,grip,measured,using,calibrated,instruments,Arm,was,defined,arm,Low,sex,specific,lowest,quintiles,respectively,Cox,proportional,hazards,models,yielded,ratios,HRs,confidence,intervals,CIs,risks,relation,Results,During,median,follow,up,died,appendicular,total,adjusted,sociodemographic,characteristics,lifestyle,factors,medical,histories,Conclusion,are,associated,short,term,increased,indicating,importance,maintaining,normal,adults,All,Prospective

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