Objective To explore the association between lipid profiles and left ventricular hypertrophy in a Chinese general population. Methods We conducted a retrospective observational study to investigate the relationship between lipid markers [including triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein (HDL) cholesterol, non-HDL-cholesterol, apolipoprotein A-I, apolipoprotein B, lipoprotein[a], and composite lipid profiles] and left ventricular hypertrophy. A total of 309,400 participants of two populations (one from Beijing and another from nationwide) who underwent physical examinations at different health management centers between 2009 and 2018 in China were included in the cross-sectional study. 7,475 participants who had multiple physical examinations and initially did not have left ventricular hypertrophy constituted a longitudinal cohort to analyze the association between lipid markers and the new-onset of left ventricular hypertrophy. Left ventricular hypertrophy was measured by echocardiography and defined as an end-diastolic thickness of the interventricular septum or left ventricle posterior wall > 11 mm. The Logistic regression model was used in the cross-sectional study. Cox model and Cox model with restricted cubic splines were used in the longitudinal cohort. Results In the cross-sectional study, for participants in the highest tertile of each lipid marker compared to the respective lowest, triglycerides [odds ratio (OR): 1.250, 95％CI: 1.060 to 1.474], HDL-cholesterol (OR: 0.780, 95％CI: 0.662 to 0.918), and lipoprotein(a) (OR: 1.311, 95％CI: 1.115 to 1.541) had an association with left ventricular hypertrophy. In the longitudinal cohort, for participants in the highest tertile of each lipid marker at the baseline compared to the respective lowest, triglycerides [hazard ratio (HR): 3.277, 95％CI: 1.720 to 6.244], HDL-cholesterol (HR: 0.516, 95％CI: 0.283 to 0.940), non-HDL-cholesterol (HR: 2.309, 95％CI: 1.296 to 4.112), apolipoprotein B (HR: 2.244, 95％CI: 1.251 to 4.032) showed an association with new-onset left ventricular hypertrophy. In the Cox model with forward stepwise selection, triglycerides were the only lipid markers entered into the final model. Conclusion Lipids levels, especially triglycerides, are associated with left ventricular hypertrophy. Controlling triglycerides level potentiate to be a strategy in harnessing cardiac remodeling but deserve to be further investigated.

Xuewei Huang;Keqiong Deng;Juanjuan Qin;Fang Lei;Xingyuan Zhang;Wenxin Wang;Lijin Lin;Yuming Zheng;Dongai Yao;Huiming Lu;Feng Liu;Lidong Chen;Guilan Zhang;Yueping Liu;Qiongyu Yang;Jingjing Cai;Zhigang She;Hongliang Li

Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Physical Examination Center,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Cardiology,Center Hospital of Huanggang,Huanggang,Hubei 438000,China;Huanggang Institute of Translation Medicine,Huanggang,Hubei 438000,China;Department of Cardiology;Institute of Model Animal;School of Basic Medical Science,Wuhan University,Wuhan 430071,China;Physical Examination Center,The Central Hospital of Wuhan,Wuhan 430014,China;General Medical Department,CR&WISCO General Hospital,Wuhan 430000,China;Information Center,Hubei Provincial Hospital of Integrated Chinese and Western Medicine,Wuhan 430015,China;Department of Medical Examination Center,Taihe Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China;Department of Health Management,Xiaogan Hospital Affiliated to Wuhan University of Science and Technology,Xiaogan,Hubei 432000,China;Basic Medical Laboratory,General Hospital of Central Theater Command,Wuhan 430070,China;Hubei Key Laboratory of Central Nervous System Tumor and Intervention,Wuhan 430070,China;Chinese Medicine Center,Shiyan Renmin Hospital,Shiyan,Hubei 442000,China;Department of Cardiology,The Third Xiangya Hospital,Central South University,Changsha 410000,China

中国医学科学杂志（英文版）

[1]Xuewei Huang;Keqiong Deng;Juanjuan Qin;Fang Lei;Xingyuan Zhang;Wenxin Wang;Lijin Lin;Yuming Zheng;Dongai Yao;Huiming Lu;Feng Liu;Lidong Chen;Guilan Zhang;Yueping Liu;Qiongyu Yang;Jingjing Cai;Zhigang She;Hongliang Li-.Association Between Lipid Profiles and Left Ventricular Hypertrophy: New Evidence from a Retrospective Study)[J].中国医学科学杂志（英文版）,2022(02):103-117

Hypertrophy

Association,Between,Profiles,Left,Ventricular,New,Evidence,from,Retrospective,Study,Objective,To,explore,association,between,lipid,profiles,left,hypertrophy,Chinese,general,Methods,We,conducted,retrospective,observational,study,relationship,markers,including,triglycerides,total,cholesterol,density,HDL,apolipoprotein,composite,participants,two,populations,one,Beijing,another,nationwide,who,underwent,physical,examinations,different,health,management,centers,China,were,included,cross,sectional,had,multiple,initially,did,have,constituted,longitudinal,cohort,analyze,new,onset,was,measured,by,echocardiography,defined,end,diastolic,thickness,interventricular,septum,ventricle,posterior,wall,regression,used,Cox,restricted,cubic,splines,Results,In,highest,tertile,each,compared,respective,lowest,odds,ratio,baseline,hazard,showed,forward,stepwise,selection,only,entered,into,final,Conclusion,Lipids,levels,especially,associated,Controlling,potentiate,strategy,harnessing,cardiac,remodeling,but,deserve,further,investigated

0.446506