Background::Abnormal lipids are strong predictors of cardiovascular disease in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). However, the potential associations of insulin resistance (IR) and beta-cell function (BCF) with abnormal lipids in newly diagnosed T1DM or T2DM patients are not fully understood.Methods::A cross-sectional survey of 15,928 participants was conducted. Homeostasis model assessment and postprandial C-peptide levels were used to estimate IR and BCF. A restricted cubic spline (RCS) nested in binary logistic regression was used to examine the associations of IR and BCF with abnormal lipids.Results::High triglyceride (TG), low high-density lipoprotein cholesterol, and high low-density lipoprotein cholesterol (LDL-C) accounted for 49.7%, 47.8%, and 59.2% of the participants, respectively. In multivariable analysis, high IR was associated with an increased risk of high TGs ( P for trend <0.001) in T1DM and is associated with an elevated risk of high TG and low HDL-C (all P for trend <0.01) in T2DM. Low BCF was not associated with risks of dyslipidemia in patients with T1DM or T2DM after adjustment for potential confounders. Conclusion::High IR had different associations with the risk of dyslipidemia in newly diagnosed T1DM and T2DM patients, suggesting that early treatment that improves IR may benefit abnormal lipid metabolism.

Beta-cell function;Dyslipidemia;Insulin resistance;Type 1 diabetes;Type 2 diabetes

Tang Xiaohan;Yan Xiang;Zhou Houde;Huang Gan;Niu Xiaohong;Jiang Hongwei;Su Heng;Yang Xilin;Li Xia;Zhou Zhiguang

Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China;Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China;Department of Endocrinology, Heji Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046000, China;Department of Endocrinology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, China;Department of Endocrinology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan, Kunming, Yunnan 650032, China;Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China

中华医学杂志（英文版）

[1]Tang Xiaohan;Yan Xiang;Zhou Houde;Huang Gan;Niu Xiaohong;Jiang Hongwei;Su Heng;Yang Xilin;Li Xia;Zhou Zhiguang-.Associations of insulin resistance and beta-cell function with abnormal lipid profile in newly diagnosed diabetes)[J].中华医学杂志（英文版）,2022(21):2554-2562

Associations,insulin,resistance,beta,cell,function,abnormal,profile,newly,diagnosed,diabetes,Background,Abnormal,lipids,are,strong,predictors,cardiovascular,disease,type,mellitus,T1DM,T2DM,However,potential,associations,BCF,patients,not,fully,understood,Methods,cross,sectional,survey,participants,was,conducted,Homeostasis,model,assessment,postprandial,peptide,levels,were,used,estimate,restricted,cubic,spline,RCS,nested,binary,logistic,regression,examine,Results,High,triglyceride,low,high,density,lipoprotein,cholesterol,LDL,accounted,respectively,multivariable,analysis,associated,increased,TGs,trend,elevated,HDL,all,Low,risks,dyslipidemia,after,adjustment,confounders,Conclusion,had,different,suggesting,that,early,treatment,improves,may,benefit,metabolism,Beta,Dyslipidemia,Insulin,Type

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