典型文献
Endogenous versus exogenous cell replacement for Parkinson's disease:where are we at and where are we going?
文献摘要：
Parkinson's disease is the second most common neurodegenerative disease and has currently no effective treatment,one that would be able to stop or reverse the loss of dopaminergic neurons in the substantia nigra pars compacta.In addition,Parkinson's disease diagnosis is typically done when a significant percentage of the dopaminergic neurons is already lost.In neurodegenerative disorders,some therapeutic strategies could be effective only at inhibiting further degeneration;on the other hand,cell replacement therapies aim at replacing lost neurons,an approach that would be ideal for the treatment of Parkinson's disease.Many cell replacement therapies have been tested since the 1970s in the field of Parkinson's disease;however,there are still significant limitations prohibiting a successful clinical application.From the first fetal midbrain intrastriatal graft to the most recent conversion of astrocytes into dopaminergic neurons,we have gained equally,significant insights and questions still looking for an answer.This review aims to summarize the main milestones in cell replacement approaches against Parkinson's disease.By focusing on achievements and failures,as well as on the additional research steps needed,we aim to provide perspective on how future cell replacement therapies treats Parkinson's disease.
文献关键词：
中图分类号：
作者姓名：
Theodora Mourtzi;Ilias Kazanis
作者机构：
Laboratory of Developmental Biology,Department of Biology,University of Patras,Patras,Greece
文献出处：
引用格式：
[1]Theodora Mourtzi;Ilias Kazanis-.Endogenous versus exogenous cell replacement for Parkinson's disease:where are we at and where are we going?)[J].中国神经再生研究（英文版）,2022(12):2637-2642
A类：
prohibiting,intrastriatal
B类：
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AB值：
0.572721
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