典型文献
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy
文献摘要：
Increasing evidence shows that autophagy impairment is involved in the pathogenesis and progression of neurodegenerative diseases including Parkinson's disease(PD).We previously identified a natural alkaloid named corynoxine B(Cory B)as a neuronal autophagy inducer.However,its brain permeability is relatively low,which hinders its potential use in treating PD.Thus we synthesized various derivatives of Cory B to find more potent autophagy inducers with improved brain bioavailability.In this study,we evaluated the autophagy-enhancing effect of CB6 derivative and its neuroprotective action against PD in vitro and in vivo.We showed that CB6(5-40 μM)dose-dependently accelerated autophagy flux in cultured N2a neural cells through activating the PIK3C3 complex and promoting PI3P production.In MPP+-treated PC12 cells,CB6 inhibited cell apoptosis and increased cell viability by inducing autophagy.In MPTP-induced mouse model of PD,oral administration of CB6(10,20 mg·kg-1.d-1,for 21 days)significantly improved motor dysfunction and prevented the loss of dopaminergic neurons in the striatum and substantia nigra pars compacta.Collectively,compound CB6 is a brain-permeable autophagy enhancer via PIK3C3 complex activation,which may help the prevention or treatment of PD.
文献关键词：
中图分类号：
作者姓名：
Zhou Zhu;Liang-feng Liu;Cheng-fu Su;Jia Liu;Benjamin Chun-Kit Tong;Ashok lyaswamy;Senthilkumar Krishnamoorthi;Sravan Gopalkrishnashetty Sreenivasmurthy;Xin-jie Guan;Yu-xuan Kan;Wen-jian Xie;Chen-liang Zhao;King-ho Cheung;Jia-hong Lu;Jie-qiong Tan;Hong-jie Zhang;Ju-xian Song;Min Li
作者机构：
Mr.&Mrs.Ko Chi-Ming Centre for Parkinson's Disease Research,School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,SAR,China;School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,SAR,China;institute for Research and Continuing Education,Hong Kong Baptist University,Shenzhen 518057,China;Limin Pharmaceutical Factory,Livzon Group Limited,Shaoguan 512028,China;State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macau,SAR,China;Center for Medical Genetics and Hunan Key Laboratory of Animal Model for Human Diseases,School of Life Sciences,Central South University,Changsha 410078,China;Medical College of Acupuncture-Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou 510006,China
文献出处：
引用格式：
[1]Zhou Zhu;Liang-feng Liu;Cheng-fu Su;Jia Liu;Benjamin Chun-Kit Tong;Ashok lyaswamy;Senthilkumar Krishnamoorthi;Sravan Gopalkrishnashetty Sreenivasmurthy;Xin-jie Guan;Yu-xuan Kan;Wen-jian Xie;Chen-liang Zhao;King-ho Cheung;Jia-hong Lu;Jie-qiong Tan;Hong-jie Zhang;Ju-xian Song;Min Li-.Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy)[J].中国药理学报（英文版）,2022(10):2511-2526
A类：
Corynoxine,CB6,PIK3C3,corynoxine,Cory,PI3P
B类：
prevents,Parkinsonian,toxicity,mice,by,inducing,complex,autophagy,Increasing,evidence,shows,that,impairment,involved,pathogenesis,progression,neurodegenerative,diseases,including,We,previously,identified,natural,alkaloid,named,neuronal,However,its,brain,permeability,relatively,low,which,hinders,potential,treating,Thus,synthesized,various,derivatives,find,more,inducers,improved,bioavailability,this,study,evaluated,enhancing,effect,neuroprotective,action,against,vitro,vivo,showed,dose,dependently,accelerated,flux,cultured,N2a,neural,cells,through,activating,promoting,production,MPP+,treated,PC12,inhibited,apoptosis,increased,viability,MPTP,induced,mouse,model,oral,administration,days,significantly,motor,dysfunction,prevented,loss,dopaminergic,neurons,striatum,substantia,nigra,pars,compacta,Collectively,compound,permeable,enhancer,activation,may,help,prevention,treatment
AB值：
0.576203
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
