典型文献
The diverse role of the raphe 5-HTergic systems in epilepsy
文献摘要：
The raphe nuclei comprise nearly all of 5-hydroxytryptaminergic(5-HTergic)neurons in the brain and are widely acknowledged to participate in the modulation of neural excitability."Excitability-inhibition imbalance"results in a variety of brain disorders,including epilepsy.Epilepsy is a common neurological disorder characterized by hypersynchronous epileptic seizures accompanied by many psychological,social,cognitive consequences.Current antiepileptic drugs and other therapeutics are not ideal to control epilepsy and its comorbidities.Cumulative evidence suggests that the raphe nuclei and 5-HTergic system play an important role in epilepsy and epilepsy-associated comorbidities.Seizure activities propagate to the raphe nuclei and induce various alterations in different subregions of the raphe nuclei at the cellular and molecular levels.Intervention of the activity of raphe nuclei and raphe 5-HTergic system with pharmacological or genetic approaches,deep brain stimulation or optogenetics produces indeed diverse and even contradictory effects on seizure and epilepsy-associated comorbidities in different epilepsy models.Nevertheless,there are still many open questions left,especially regarding to the relationship between 5-HTergic neural circuit and epilepsy.Understanding of 5-HTergic network in a circuit-and molecule-specific way may not only be therapeutically relevant for increasing the drug specificity and precise treatment in epilepsy,but also provide critical hints for other brain disorders with abnormal neural excitability.In this review we focus on the roles of the raphe 5-HTergic system in epilepsy and epilepsy-associated comorbidities.Besides,further perspectives about the complexity and diversity of the raphe nuclei in epilepsy are also addressed.
文献关键词：
中图分类号：
作者姓名：
He-ming Cheng;Chen-shu Gao;Qiu-wen Lou;Zhong Chen;Yi Wang
作者机构：
Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China;Epilepsy Center,Department of Neurology,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310058,China
文献出处：
引用格式：
[1]He-ming Cheng;Chen-shu Gao;Qiu-wen Lou;Zhong Chen;Yi Wang-.The diverse role of the raphe 5-HTergic systems in epilepsy)[J].中国药理学报（英文版）,2022(11):2777-2788
A类：
HTergic,hydroxytryptaminergic,Excitability,hypersynchronous
B类：
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AB值：
0.495922
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