典型文献
ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signaling
文献摘要：
The mechanisms that regulate neural stem cell (NSC) lineage progression and maintain NSCs within different domains of the adult neural stem cell niche, the subventricular zone are not well defined. Quiescent NSCs are arranged at the apical ventricular wall, while mitotically activated NSCs are found in the basal, vascular region of the subventricular zone. Here, we found that ADAM10 (a disintegrin and metalloproteinase 10) is essential in NSC association with the ventricular wall, and via this adhesion to the apical domain, ADAM10 regulates the switch from quiescent and undifferentiated NSC to an actively proliferative and differentiating cell state. Processing of JAMC (junctional adhesion molecule C) by ADAM10 increases Rap1GAP activity. This molecular machinery promotes NSC transit from the apical to the basal compartment and subsequent lineage progression. Understanding the molecular mechanisms responsible for regulating the proper positioning of NSCs within the subventricular zone niche and lineage progression of NSCs could provide new targets for drug development to enhance the regenerative properties of neural tissue.
文献关键词：
中图分类号：
作者姓名：
Nadia McMillan;Gregory W.Kirschen;Sanket Desai;Emma Xia;Stella E.Tsirka;Adan Aguirre
作者机构：
Program in Neuroscience and Medical Scientist Training Program,Renaissance School of Medicine at Stony Brook University,Stony Brook,NY,USA;Department of Pharmacological Sciences,Renaissance School of Medicine at Stony Brook University,Stony Brook,NY,USA;Department of Neurology,Beth Israel Deaconess Medical Center/Harvard Medical School,Boston,MA,USA;Department of Gynecology and Obstetrics,Johns Hopkins Hospital,Baltimore,MD,USA
文献出处：
引用格式：
[1]Nadia McMillan;Gregory W.Kirschen;Sanket Desai;Emma Xia;Stella E.Tsirka;Adan Aguirre-.ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signaling)[J].中国神经再生研究（英文版）,2022(11):2472-2483
A类：
JAMC,RAP1Gap,Quiescent,mitotically
B类：
ADAM10,facilitates,rapid,neural,stem,cell,cycling,positioning,within,subventricular,zone,niche,via,signaling,mechanisms,that,lineage,progression,maintain,NSCs,domains,adult,are,not,well,defined,arranged,apical,wall,while,activated,found,basal,vascular,region,Here,disintegrin,metalloproteinase,essential,association,this,adhesion,regulates,switch,from,quiescent,undifferentiated,actively,proliferative,differentiating,state,Processing,junctional,molecule,by,increases,Rap1GAP,activity,This,molecular,machinery,promotes,transit,compartment,subsequent,Understanding,responsible,regulating,could,provide,new,targets,drug,development,enhance,regenerative,properties,tissue
AB值：
0.478537
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
