典型文献
Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activation
文献摘要：
INTRODUCTION Human dental pulp stem cells (hDPSCs) are rich in human dental pulp tissues.1 Recently, hDPSCs have been substantially consid-ered for several applications in the regenerative medicine and tissue engineering fields due to their benefits over the other sources. First, they are easily accessible and are easily obtained during routine dental procedures without ethical concerns, and can retain their stem cell properties even after long cryopreserva-tion.2 Second, hDPSCs have a great potential with multilineage differentiation; they can differentiate into odontogenic lineage that express gene-specific markers, such as runt-related transcrip-tion factor 2 (RUNX2), alkaline phosphatase (ALP), dentin matrix protein-1 (DMP-1), and dentin sialophosphoprotein (DSPP).3 Several hDPSCs transplantation studies have shown regenerative capacity of a dentin/pulp-like structure in animal models.1,4–6 Therefore, understanding the biological mechanisms of hDPSC differentiation is essential for providing successful hDPSCs engineering strategies in dental pulp therapy.
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中图分类号：
作者姓名：
So Mi Jeon;Je Sun Lim;Su Hwan Park;Hyung Joon Kim;Hyung-Ryong Kim;Jong-Ho Lee
作者机构：
Department of Health Sciences,The Graduate School of Dong-A University,Busan,Republic of Korea;Department of Oral Physiology,Periodontal Diseases Signaling Network Research Center,Dental and Life Science Institute,School of Dentistry,Pusan National University,Yangsan,Republic of Korea;Department of Pharmacology,College of Dentistry,Jeonbuk National University,Jeonju,Republic of Korea;Department of Biomedical Sciences,Dong-A University,Busan,Republic of Korea
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引用格式：
[1]So Mi Jeon;Je Sun Lim;Su Hwan Park;Hyung Joon Kim;Hyung-Ryong Kim;Jong-Ho Lee-.Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activation)[J].国际口腔科学杂志（英文版）,2022(02):164-173
A类：
cryopreserva,multilineage
B类：
Blockade,L1,signaling,promotes,osteo,odontogenic,differentiation,through,Ras,activation,INTRODUCTION, Human,dental,pulp,stem,cells,hDPSCs,are,rich,human,tissues,Recently,have,been,substantially,consid,ered,several,applications,regenerative,medicine,engineering,fields,due,their,benefits,over,other,sources,First,they,easily,accessible,obtained,during,routine,procedures,without,ethical,concerns,can,retain,properties,even,after,long,Second,great,potential,differentiate,into,that,express,specific,markers,such,runt,related,transcrip,RUNX2,alkaline,phosphatase,ALP,dentin,matrix,DMP,sialophosphoprotein,DSPP,Several,transplantation,studies,shown,capacity,like,structure,animal,models,Therefore,understanding,biological,mechanisms,essential,providing,successful,strategies,therapy
AB值：
0.646863
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