典型文献
Derlin-1 and TER94/VCP/p97 are required for intestinal homeostasis
文献摘要：
Adult stem cells are critical for the maintenance of residential tissue homeostasis and functions.However,the roles of cellular protein homeostasis maintenance in stem cell proliferation and tissue homeostasis are not fully understood.Here,we find that Derlin-1 and TER94N/CP/p97,components of the endoplasmic reticulum(ER)-associated degradation(ERAD)pathway,restrain intestinal stem cell proliferation to maintain intestinal homeostasis in adult Drosophila.Depleting any of them results in increased stem cell proliferation and midgut homeostasis disruption.Derlin-1 is specifically localized in the ER of progenitors,and its C-terminus is required for its function.Interestingly,we find that increased stem cell proliferation is resulted from elevated ROS levels and activated JNK signaling in Derlin-1-or TER94-deficient progenitors.Further removal of reactive oxygen species(ROS)or inhibition of JNK signaling almost completely suppresses increased stem cell proliferation.Together,these data demonstrate that the ERAD pathway is critical for stem cell proliferation and tissue homeostasis.Thus,we provide insights into our understanding of the mechanisms underlying cellular protein homeostasis maintenance(ER protein quality control)in tissue homeostasis and tumor development.
文献关键词：
中图分类号：
作者姓名：
Fuli Liu;Hang Zhao;Ruiyan Kong;Lin Shi;Zhengran Li;Rui Ma;Huiqing Zhao;Zhouhua Li
作者机构：
College of Life Sciences,Capital Normal University,Beijing 100048,China;Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China
文献出处：
引用格式：
[1]Fuli Liu;Hang Zhao;Ruiyan Kong;Lin Shi;Zhengran Li;Rui Ma;Huiqing Zhao;Zhouhua Li-.Derlin-1 and TER94/VCP/p97 are required for intestinal homeostasis)[J].遗传学报,2022(03):195-207
A类：
TER94,p97,TER94N
B类：
Derlin,VCP,are,required,intestinal,homeostasis,Adult,stem,cells,critical,maintenance,residential,tissue,functions,However,roles,cellular,protein,proliferation,not,fully,understood,Here,find,that,components,endoplasmic,reticulum,associated,degradation,ERAD,pathway,restrain,maintain,adult,Drosophila,Depleting,any,them,results,increased,midgut,disruption,specifically,localized,progenitors,its,terminus,Interestingly,resulted,from,elevated,ROS,levels,activated,JNK,signaling,deficient,Further,removal,reactive,oxygen,species,inhibition,almost,completely,suppresses,Together,these,data,demonstrate,Thus,provide,insights,into,our,understanding,mechanisms,underlying,quality,control,tumor,development
AB值：
0.489045
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
